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- W2017991256 abstract "In order to achieve efficient siRNA delivery to the brain, we designed a novel polyion complex (PIC) micelles composed of rabies virus glycoprotein (RVG) peptide tagged PEGylated polyasparthydrazide (PAHy) derivatives. The synthesized derivatives were characterized using (1)H NMR. The PIC micelles were formed by electrostatic attraction between the polymer and siRNA. Then the micelles were decorated with RVG using PEG as a linker. The physiochemical properties of micelles, such as gel retardation assay, zeta potential, particle size, morphology and serum stability, were investigated. Moreover, the cytotoxicity, cellular uptake, gene silencing efficiency and in vivo distribution of micelles were also evaluated systematically. Compared with unmodified micelles, RVG-modified micelles can be more easily internalized by the neuro2a cells and efficiently silence gene expression. In vivo animal experiments further confirmed that RVG modified micelles had brain targeting ability. These results demonstrated that RVG-modified micelles were promising carriers for siRNA delivery to the brain." @default.
- W2017991256 created "2016-06-24" @default.
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- W2017991256 date "2015-06-01" @default.
- W2017991256 modified "2023-10-16" @default.
- W2017991256 title "Polyion complex micelles composed of pegylated polyasparthydrazide derivatives for siRNA delivery to the brain" @default.
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- W2017991256 doi "https://doi.org/10.1016/j.jcis.2015.01.043" @default.
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