FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017994898> ?p ?o ?g. }

• W2017994898 endingPage "2108" @default.
• W2017994898 startingPage "2105" @default.
• W2017994898 abstract "Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the SIRT1 deacetylase and activates the Forkhead transcription factor Foxo3a. Knockdown of Foxo3a expression inhibited the starvation-induced increase in SIRT1 expression. Stimulation of SIRT1 transcription by Foxo3a was mediated through two p53 binding sites present in the SIRT1 promoter, and a nutrient-sensitive physical interaction was observed between Foxo3a and p53. SIRT1 expression was not induced in starved p53-deficient mice. Thus, in mammalian cells, p53, Foxo3a, and SIRT1, three proteins separately implicated in aging, constitute a nutrient-sensing pathway." @default.
• W2017994898 created "2016-06-24" @default.
• W2017994898 creator A5011179194 @default.
• W2017994898 creator A5053967338 @default.
• W2017994898 creator A5085211904 @default.
• W2017994898 date "2004-12-17" @default.
• W2017994898 modified "2023-10-10" @default.
• W2017994898 title "Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway" @default.
• W2017994898 cites W1966828006 @default.
• W2017994898 cites W1969408132 @default.
• W2017994898 cites W1974190379 @default.
• W2017994898 cites W1980017984 @default.
• W2017994898 cites W1985308585 @default.
• W2017994898 cites W1987738803 @default.
• W2017994898 cites W1991080848 @default.
• W2017994898 cites W2008257691 @default.
• W2017994898 cites W2010255232 @default.
• W2017994898 cites W2012753961 @default.
• W2017994898 cites W2056462946 @default.
• W2017994898 cites W2060107244 @default.
• W2017994898 cites W2069414088 @default.
• W2017994898 cites W2074740541 @default.
• W2017994898 cites W2124595934 @default.
• W2017994898 cites W2124898423 @default.
• W2017994898 cites W2136545880 @default.
• W2017994898 cites W2142205521 @default.
• W2017994898 cites W2157649587 @default.
• W2017994898 cites W2171317581 @default.
• W2017994898 cites W2171391341 @default.
• W2017994898 cites W2314683555 @default.
• W2017994898 cites W4229704949 @default.
• W2017994898 cites W4362060345 @default.
• W2017994898 doi "https://doi.org/10.1126/science.1101731" @default.
• W2017994898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15604409" @default.
• W2017994898 hasPublicationYear "2004" @default.
• W2017994898 type Work @default.
• W2017994898 sameAs 2017994898 @default.
• W2017994898 citedByCount "614" @default.
• W2017994898 countsByYear W20179948982012 @default.
• W2017994898 countsByYear W20179948982013 @default.
• W2017994898 countsByYear W20179948982014 @default.
• W2017994898 countsByYear W20179948982015 @default.
• W2017994898 countsByYear W20179948982016 @default.
• W2017994898 countsByYear W20179948982017 @default.
• W2017994898 countsByYear W20179948982018 @default.
• W2017994898 countsByYear W20179948982019 @default.
• W2017994898 countsByYear W20179948982020 @default.
• W2017994898 countsByYear W20179948982021 @default.
• W2017994898 countsByYear W20179948982022 @default.
• W2017994898 countsByYear W20179948982023 @default.
• W2017994898 crossrefType "journal-article" @default.
• W2017994898 hasAuthorship W2017994898A5011179194 @default.
• W2017994898 hasAuthorship W2017994898A5053967338 @default.
• W2017994898 hasAuthorship W2017994898A5085211904 @default.
• W2017994898 hasConcept C104317684 @default.
• W2017994898 hasConcept C127561419 @default.
• W2017994898 hasConcept C138885662 @default.
• W2017994898 hasConcept C142796444 @default.
• W2017994898 hasConcept C173396325 @default.
• W2017994898 hasConcept C179926584 @default.
• W2017994898 hasConcept C185592680 @default.
• W2017994898 hasConcept C18903297 @default.
• W2017994898 hasConcept C2776030549 @default.
• W2017994898 hasConcept C2776536020 @default.
• W2017994898 hasConcept C2908554999 @default.
• W2017994898 hasConcept C41895202 @default.
• W2017994898 hasConcept C55493867 @default.
• W2017994898 hasConcept C62478195 @default.
• W2017994898 hasConcept C86339819 @default.
• W2017994898 hasConcept C86803240 @default.
• W2017994898 hasConcept C95444343 @default.
• W2017994898 hasConceptScore W2017994898C104317684 @default.
• W2017994898 hasConceptScore W2017994898C127561419 @default.
• W2017994898 hasConceptScore W2017994898C138885662 @default.
• W2017994898 hasConceptScore W2017994898C142796444 @default.
• W2017994898 hasConceptScore W2017994898C173396325 @default.
• W2017994898 hasConceptScore W2017994898C179926584 @default.
• W2017994898 hasConceptScore W2017994898C185592680 @default.
• W2017994898 hasConceptScore W2017994898C18903297 @default.
• W2017994898 hasConceptScore W2017994898C2776030549 @default.
• W2017994898 hasConceptScore W2017994898C2776536020 @default.
• W2017994898 hasConceptScore W2017994898C2908554999 @default.
• W2017994898 hasConceptScore W2017994898C41895202 @default.
• W2017994898 hasConceptScore W2017994898C55493867 @default.
• W2017994898 hasConceptScore W2017994898C62478195 @default.
• W2017994898 hasConceptScore W2017994898C86339819 @default.
• W2017994898 hasConceptScore W2017994898C86803240 @default.
• W2017994898 hasConceptScore W2017994898C95444343 @default.
• W2017994898 hasIssue "5704" @default.
• W2017994898 hasLocation W20179948981 @default.
• W2017994898 hasLocation W20179948982 @default.
• W2017994898 hasOpenAccess W2017994898 @default.
• W2017994898 hasPrimaryLocation W20179948981 @default.
• W2017994898 hasRelatedWork W1964550779 @default.
• W2017994898 hasRelatedWork W2800322456 @default.
• W2017994898 hasRelatedWork W3029482091 @default.
• W2017994898 hasRelatedWork W3103789129 @default.
• W2017994898 hasRelatedWork W3157667906 @default.

• next