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- W2017995775 abstract "Insulin was employed as a stimulant in our continuing investigations of the molecular mechanisms involved in the coordinate control of cellular metabolism and growth. Incubation of chicken embryo fibroblasts for 16 hours in media containing 0–0.1 U insulin/ml resulted in a 17-fold increase in the rate of 3H-thymidine incorporation into DNA. Concomitantly, there were graded increases in intracellular K+ (14%) and Mg2+ (22%) and no significant change in Ca2+. These changes in cation content occurred within 10 to 30 minutes and preceded the changes in 3H-thymidine incorporation. Insulin produced a consistent graded decrease in externally bound Mg2+ and Ca2+ and a concomitant increase in bound Na+ and K+ with no significant change in the rates of K+ and Mg2+ efflux. The results are consistent with the concept of Mg2+ as a second messenger for insulin action, as well as with the more general hypothesis that Mg2+ is the central agent in the coordinate control of metabolism and growth in animal cells." @default.
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- W2017995775 date "1978-09-01" @default.
- W2017995775 modified "2023-10-14" @default.
- W2017995775 title "Membrane bound and cellular cationic changes associated with insulin stimulation of cultured cells" @default.
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- W2017995775 doi "https://doi.org/10.1002/jcp.1040960302" @default.
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