Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017997684> ?p ?o ?g. }
- W2017997684 endingPage "196" @default.
- W2017997684 startingPage "177" @default.
- W2017997684 abstract "Abstract The receptor tyrosine kinase Met is dysregulated in several human cancers including osteosarcoma (OSA) in which overexpression is a negative prognostic indicator and enforced Met expression in normal osteoblasts leads to genomic instability and malignant transformation. Met is also known to be inappropriately expressed in canine OSA tumour samples and cell lines. The purpose of this study was to evaluate the potential utility of an orally bioavailable small molecule Met inhibitor, PF2362376, against canine OSA cell lines as a prelude to future clinical work. PF2362376 inhibited phosphorylation of Met, Gab‐1, Erk and Akt, but not of Src or STAT3. Furthermore, PF2362376 inhibited proliferation of canine OSA cell lines and induced cell death at biologically achievable concentrations. Last, activities associated with Met signalling including migration, invasion, branching morphogenesis and colony formation in soft agar were blocked by PF2362376. These studies support the notion that Met is a relevant target for therapeutic intervention in OSA." @default.
- W2017997684 created "2016-06-24" @default.
- W2017997684 creator A5018133039 @default.
- W2017997684 creator A5021474295 @default.
- W2017997684 creator A5071909380 @default.
- W2017997684 creator A5074923974 @default.
- W2017997684 creator A5085260686 @default.
- W2017997684 date "2007-08-10" @default.
- W2017997684 modified "2023-10-14" @default.
- W2017997684 title "A novel small molecule Met inhibitor, PF2362376, exhibits biological activity against osteosarcoma" @default.
- W2017997684 cites W1426393029 @default.
- W2017997684 cites W1503840647 @default.
- W2017997684 cites W153220058 @default.
- W2017997684 cites W1649526546 @default.
- W2017997684 cites W1963945928 @default.
- W2017997684 cites W1964261321 @default.
- W2017997684 cites W1965641790 @default.
- W2017997684 cites W1972607682 @default.
- W2017997684 cites W1973966923 @default.
- W2017997684 cites W1975348357 @default.
- W2017997684 cites W1977436845 @default.
- W2017997684 cites W1979390267 @default.
- W2017997684 cites W1982518280 @default.
- W2017997684 cites W1984294894 @default.
- W2017997684 cites W1985562847 @default.
- W2017997684 cites W1990765972 @default.
- W2017997684 cites W1991566510 @default.
- W2017997684 cites W1999523291 @default.
- W2017997684 cites W2001046604 @default.
- W2017997684 cites W2001276579 @default.
- W2017997684 cites W2005092992 @default.
- W2017997684 cites W2005638713 @default.
- W2017997684 cites W2007904495 @default.
- W2017997684 cites W2011717936 @default.
- W2017997684 cites W2012792646 @default.
- W2017997684 cites W2013678879 @default.
- W2017997684 cites W2016774655 @default.
- W2017997684 cites W2018547695 @default.
- W2017997684 cites W2018672261 @default.
- W2017997684 cites W2019573100 @default.
- W2017997684 cites W2022527563 @default.
- W2017997684 cites W2025772881 @default.
- W2017997684 cites W2029587780 @default.
- W2017997684 cites W2030857804 @default.
- W2017997684 cites W2031504285 @default.
- W2017997684 cites W2035174231 @default.
- W2017997684 cites W2041204531 @default.
- W2017997684 cites W2043671544 @default.
- W2017997684 cites W2048097275 @default.
- W2017997684 cites W2050825441 @default.
- W2017997684 cites W2052915894 @default.
- W2017997684 cites W2054042846 @default.
- W2017997684 cites W2059336557 @default.
- W2017997684 cites W2059950450 @default.
- W2017997684 cites W2060991704 @default.
- W2017997684 cites W2068994296 @default.
- W2017997684 cites W2078325464 @default.
- W2017997684 cites W2079642245 @default.
- W2017997684 cites W2091753221 @default.
- W2017997684 cites W2092324321 @default.
- W2017997684 cites W2103959132 @default.
- W2017997684 cites W2105191013 @default.
- W2017997684 cites W2105677187 @default.
- W2017997684 cites W2115332043 @default.
- W2017997684 cites W2118310862 @default.
- W2017997684 cites W2121562333 @default.
- W2017997684 cites W2126150441 @default.
- W2017997684 cites W2135201591 @default.
- W2017997684 cites W2136390065 @default.
- W2017997684 cites W2138309116 @default.
- W2017997684 cites W2147150467 @default.
- W2017997684 cites W2148971037 @default.
- W2017997684 cites W2153116079 @default.
- W2017997684 cites W2157539187 @default.
- W2017997684 cites W2159118796 @default.
- W2017997684 cites W2162577349 @default.
- W2017997684 cites W2166952908 @default.
- W2017997684 cites W2168918909 @default.
- W2017997684 cites W2170090299 @default.
- W2017997684 cites W2330829715 @default.
- W2017997684 cites W27278923 @default.
- W2017997684 cites W2946205580 @default.
- W2017997684 cites W4234832353 @default.
- W2017997684 cites W4246742253 @default.
- W2017997684 cites W4300710884 @default.
- W2017997684 doi "https://doi.org/10.1111/j.1476-5829.2007.00137.x" @default.
- W2017997684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19754789" @default.
- W2017997684 hasPublicationYear "2007" @default.
- W2017997684 type Work @default.
- W2017997684 sameAs 2017997684 @default.
- W2017997684 citedByCount "27" @default.
- W2017997684 countsByYear W20179976842012 @default.
- W2017997684 countsByYear W20179976842013 @default.
- W2017997684 countsByYear W20179976842014 @default.
- W2017997684 countsByYear W20179976842015 @default.
- W2017997684 countsByYear W20179976842016 @default.
- W2017997684 countsByYear W20179976842017 @default.
- W2017997684 countsByYear W20179976842018 @default.