FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017997921> ?p ?o ?g. }

• W2017997921 endingPage "393" @default.
• W2017997921 startingPage "390" @default.
• W2017997921 abstract "Local extension prevents curative resection in more than two-thirds of gastric cancer patients. Unfortunately, resectability is one of the main prognostic factors in these patients, and survival is longer when tumours are completely removed. Preoperative chemotherapy is an attractive concept for obtaining curative resection. Thirty-two locally advanced unresectable gastric cancer patients were enrolled in five Italian Group for the Study of Digestive Tract Cancer (GISCAD) centres. For 16 patients, surgical unresectability was based on computerized tomography scan evaluation of tumour size (four patients) and invasion of adjacent structures (12 patients), whereas in another 16 patients locally advanced disease was confirmed by laparotomy. They received weekly administration of cisplatin 40 mg m(-2), 5-fluorouracil 500 mg m(-2), epidoxorubicin 35 mg m(-2), 6S-stereoisomer of leucovorin 250 mg m(-2) and glutathione 1.5 g m(-2). From the day after to the day before each chemotherapy administration, filgrastim was administered by subcutaneous injection at a dose of 5 microg kg(-1). One cycle of therapy consisted of eight weekly treatments. Fifteen of 32 patients (47%) responded to chemotherapy, whereas 13 (41 %) had stable disease and four (12%) progressed on therapy. Of the 15 responding patients, 13 were completely resected after chemotherapy and two of them had a complete pathological response. Two clinically responding patients were found unresectable at operation because of peritoneal seeding. At a median follow-up from the start of treatment of 24 months (range 11-39 months), 10 of 13 resected patients are alive and eight are relapse free. Three patients died after 11, 12, and 14 months respectively. Toxicity was acceptable: side-effects consisted mainly of grade II National Cancer Institute common toxicity criteria (NCICTC) leucopenia and thrombocytopenia in ten patients. Neither treatment-related death nor surgical complications in patients undergoing surgery were observed. This weekly intensive regimen enabled resection in half of previously inoperable tumours with a moderate toxicity. It can be offered to patients with locally advanced unresectable gastric cancer to obtain curative resection." @default.
• W2017997921 created "2016-06-24" @default.
• W2017997921 creator A5008585325 @default.
• W2017997921 creator A5018141422 @default.
• W2017997921 creator A5037714306 @default.
• W2017997921 creator A5042028913 @default.
• W2017997921 creator A5060633488 @default.
• W2017997921 creator A5061179981 @default.
• W2017997921 creator A5067058355 @default.
• W2017997921 creator A5082021602 @default.
• W2017997921 creator A5084773667 @default.
• W2017997921 date "1998-08-01" @default.
• W2017997921 modified "2023-10-09" @default.
• W2017997921 title "Intensive weekly chemotherapy for locally advanced gastric cancer using 5-fluorouracil, cisplatin, epidoxorubicin, 6S-leucovorin, glutathione and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)" @default.
• W2017997921 cites W113401881 @default.
• W2017997921 cites W1937087099 @default.
• W2017997921 cites W1996282949 @default.
• W2017997921 cites W2006613730 @default.
• W2017997921 cites W2014248945 @default.
• W2017997921 cites W2046580132 @default.
• W2017997921 cites W2077618889 @default.
• W2017997921 cites W2078899066 @default.
• W2017997921 cites W2111513457 @default.
• W2017997921 cites W2253295367 @default.
• W2017997921 cites W2257734533 @default.
• W2017997921 cites W2261751141 @default.
• W2017997921 cites W3025567844 @default.
• W2017997921 doi "https://doi.org/10.1038/bjc.1998.505" @default.
• W2017997921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2063041" @default.
• W2017997921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9703289" @default.
• W2017997921 hasPublicationYear "1998" @default.
• W2017997921 type Work @default.
• W2017997921 sameAs 2017997921 @default.
• W2017997921 citedByCount "35" @default.
• W2017997921 countsByYear W20179979212014 @default.
• W2017997921 countsByYear W20179979212018 @default.
• W2017997921 countsByYear W20179979212019 @default.
• W2017997921 crossrefType "journal-article" @default.
• W2017997921 hasAuthorship W2017997921A5008585325 @default.
• W2017997921 hasAuthorship W2017997921A5018141422 @default.
• W2017997921 hasAuthorship W2017997921A5037714306 @default.
• W2017997921 hasAuthorship W2017997921A5042028913 @default.
• W2017997921 hasAuthorship W2017997921A5060633488 @default.
• W2017997921 hasAuthorship W2017997921A5061179981 @default.
• W2017997921 hasAuthorship W2017997921A5067058355 @default.
• W2017997921 hasAuthorship W2017997921A5082021602 @default.
• W2017997921 hasAuthorship W2017997921A5084773667 @default.
• W2017997921 hasBestOaLocation W20179979211 @default.
• W2017997921 hasConcept C121608353 @default.
• W2017997921 hasConcept C126322002 @default.
• W2017997921 hasConcept C141071460 @default.
• W2017997921 hasConcept C2776694085 @default.
• W2017997921 hasConcept C2776755627 @default.
• W2017997921 hasConcept C2777063308 @default.
• W2017997921 hasConcept C2778239845 @default.
• W2017997921 hasConcept C2779171977 @default.
• W2017997921 hasConcept C2780456651 @default.
• W2017997921 hasConcept C2780835546 @default.
• W2017997921 hasConcept C71924100 @default.
• W2017997921 hasConcept C90924648 @default.
• W2017997921 hasConceptScore W2017997921C121608353 @default.
• W2017997921 hasConceptScore W2017997921C126322002 @default.
• W2017997921 hasConceptScore W2017997921C141071460 @default.
• W2017997921 hasConceptScore W2017997921C2776694085 @default.
• W2017997921 hasConceptScore W2017997921C2776755627 @default.
• W2017997921 hasConceptScore W2017997921C2777063308 @default.
• W2017997921 hasConceptScore W2017997921C2778239845 @default.
• W2017997921 hasConceptScore W2017997921C2779171977 @default.
• W2017997921 hasConceptScore W2017997921C2780456651 @default.
• W2017997921 hasConceptScore W2017997921C2780835546 @default.
• W2017997921 hasConceptScore W2017997921C71924100 @default.
• W2017997921 hasConceptScore W2017997921C90924648 @default.
• W2017997921 hasIssue "3" @default.
• W2017997921 hasLocation W20179979211 @default.
• W2017997921 hasLocation W20179979212 @default.
• W2017997921 hasLocation W20179979213 @default.
• W2017997921 hasLocation W20179979214 @default.
• W2017997921 hasOpenAccess W2017997921 @default.
• W2017997921 hasPrimaryLocation W20179979211 @default.
• W2017997921 hasRelatedWork W180056525 @default.
• W2017997921 hasRelatedWork W2032853726 @default.
• W2017997921 hasRelatedWork W2363409655 @default.
• W2017997921 hasRelatedWork W2402385342 @default.
• W2017997921 hasRelatedWork W2406263212 @default.
• W2017997921 hasRelatedWork W2465069930 @default.
• W2017997921 hasRelatedWork W4235214737 @default.
• W2017997921 hasRelatedWork W4247856874 @default.
• W2017997921 hasRelatedWork W4249938022 @default.
• W2017997921 hasRelatedWork W4250317237 @default.
• W2017997921 hasVolume "78" @default.
• W2017997921 isParatext "false" @default.
• W2017997921 isRetracted "false" @default.
• W2017997921 magId "2017997921" @default.
• W2017997921 workType "article" @default.