FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017998911> ?p ?o ?g. }

• W2017998911 endingPage "5075" @default.
• W2017998911 startingPage "5069" @default.
• W2017998911 abstract "Abstract Context: Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans. Objective: The objective of the study was to determine the metabolic and cardiovascular interaction of β-adrenergic receptors and ANP. Design: This was a crossover study, conducted 2004–2005. Setting: The study was conducted at an academic clinical research center. Patients: Patients included 10 healthy young male subjects (body mass index 24 ± 1 kg/m2). Intervention: We infused iv incremental ANP doses (6.25, 12.5, and 25 ng/kg·min) with and without propranolol (0.20 mg/kg in divided doses followed by 0.033 mg/kg·h infusion). Metabolism was monitored through venous blood sampling, im, and sc microdialysis and indirect calorimetry. Cardiovascular changes were monitored by continuous electrocardiogram and beat-by-beat blood pressure recordings. Main Outcome Measures: Venous nonesterified fatty acid, glycerol, glucose, and insulin; and microdialysate glucose, glycerol, lactate, and pyruvate were measured. Results: ANP increased heart rate dose dependently. β-Adrenergic receptor blockade abolished the response. ANP elicited a dose-dependent increase in serum nonesterified fatty acid and glycerol concentrations. The response was not suppressed with propranolol. Venous glucose and insulin concentrations increased with ANP, both without or with propranolol. ANP induced lipid mobilization in sc adipose tissue. In skeletal muscle, microdialysate lactate increased, whereas the lactate to pyruvate ratio decreased, both with and without propranolol. Higher ANP doses increased lipid oxidation, whereas energy expenditure remained unchanged. Propranolol tended to attenuate the increase in lipid oxidation. Conclusions: Selected cardiovascular ANP effects are at least partly mediated by β-adrenergic receptor stimulation. ANP-induced changes in lipid mobilization and glycolysis are mediated by another mechanism, presumably stimulation of natriuretic peptide receptors, whereas substrate oxidation might be modulated through adrenergic mechanisms." @default.
• W2017998911 created "2016-06-24" @default.
• W2017998911 creator A5011234349 @default.
• W2017998911 creator A5013839934 @default.
• W2017998911 creator A5017690840 @default.
• W2017998911 creator A5033310756 @default.
• W2017998911 creator A5034272596 @default.
• W2017998911 creator A5048133606 @default.
• W2017998911 creator A5050547003 @default.
• W2017998911 creator A5054591711 @default.
• W2017998911 creator A5063401332 @default.
• W2017998911 creator A5066636577 @default.
• W2017998911 creator A5076447212 @default.
• W2017998911 creator A5079089312 @default.
• W2017998911 creator A5089388570 @default.
• W2017998911 date "2006-12-01" @default.
• W2017998911 modified "2023-10-12" @default.
• W2017998911 title "β-Adrenergic and Atrial Natriuretic Peptide Interactions on Human Cardiovascular and Metabolic Regulation" @default.
• W2017998911 cites W1891074596 @default.
• W2017998911 cites W1970205234 @default.
• W2017998911 cites W1973521756 @default.
• W2017998911 cites W1975344770 @default.
• W2017998911 cites W1982488301 @default.
• W2017998911 cites W1982539394 @default.
• W2017998911 cites W1983204135 @default.
• W2017998911 cites W1985691518 @default.
• W2017998911 cites W1988232724 @default.
• W2017998911 cites W2004456062 @default.
• W2017998911 cites W2019605946 @default.
• W2017998911 cites W2019669708 @default.
• W2017998911 cites W2029416726 @default.
• W2017998911 cites W2037687961 @default.
• W2017998911 cites W2045742435 @default.
• W2017998911 cites W2046595938 @default.
• W2017998911 cites W2047631720 @default.
• W2017998911 cites W2057501387 @default.
• W2017998911 cites W2078989545 @default.
• W2017998911 cites W2079577417 @default.
• W2017998911 cites W2082595450 @default.
• W2017998911 cites W2093590196 @default.
• W2017998911 cites W2123640306 @default.
• W2017998911 cites W2128680559 @default.
• W2017998911 cites W2128725121 @default.
• W2017998911 cites W2129619396 @default.
• W2017998911 cites W2135961756 @default.
• W2017998911 cites W2138427213 @default.
• W2017998911 cites W2147042397 @default.
• W2017998911 cites W2154685515 @default.
• W2017998911 cites W2166354163 @default.
• W2017998911 cites W2174936197 @default.
• W2017998911 cites W2253132512 @default.
• W2017998911 cites W2285072859 @default.
• W2017998911 cites W2329182081 @default.
• W2017998911 cites W2417939901 @default.
• W2017998911 cites W2418856739 @default.
• W2017998911 cites W4298441315 @default.
• W2017998911 doi "https://doi.org/10.1210/jc.2006-1084" @default.
• W2017998911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2072963" @default.
• W2017998911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16984990" @default.
• W2017998911 hasPublicationYear "2006" @default.
• W2017998911 type Work @default.
• W2017998911 sameAs 2017998911 @default.
• W2017998911 citedByCount "49" @default.
• W2017998911 countsByYear W20179989112012 @default.
• W2017998911 countsByYear W20179989112013 @default.
• W2017998911 countsByYear W20179989112014 @default.
• W2017998911 countsByYear W20179989112015 @default.
• W2017998911 countsByYear W20179989112016 @default.
• W2017998911 countsByYear W20179989112017 @default.
• W2017998911 countsByYear W20179989112018 @default.
• W2017998911 countsByYear W20179989112019 @default.
• W2017998911 countsByYear W20179989112020 @default.
• W2017998911 countsByYear W20179989112022 @default.
• W2017998911 countsByYear W20179989112023 @default.
• W2017998911 crossrefType "journal-article" @default.
• W2017998911 hasAuthorship W2017998911A5011234349 @default.
• W2017998911 hasAuthorship W2017998911A5013839934 @default.
• W2017998911 hasAuthorship W2017998911A5017690840 @default.
• W2017998911 hasAuthorship W2017998911A5033310756 @default.
• W2017998911 hasAuthorship W2017998911A5034272596 @default.
• W2017998911 hasAuthorship W2017998911A5048133606 @default.
• W2017998911 hasAuthorship W2017998911A5050547003 @default.
• W2017998911 hasAuthorship W2017998911A5054591711 @default.
• W2017998911 hasAuthorship W2017998911A5063401332 @default.
• W2017998911 hasAuthorship W2017998911A5066636577 @default.
• W2017998911 hasAuthorship W2017998911A5076447212 @default.
• W2017998911 hasAuthorship W2017998911A5079089312 @default.
• W2017998911 hasAuthorship W2017998911A5089388570 @default.
• W2017998911 hasBestOaLocation W20179989111 @default.
• W2017998911 hasConcept C126322002 @default.
• W2017998911 hasConcept C134018914 @default.
• W2017998911 hasConcept C140985366 @default.
• W2017998911 hasConcept C171089720 @default.
• W2017998911 hasConcept C185592680 @default.
• W2017998911 hasConcept C2777953023 @default.
• W2017998911 hasConcept C2778069365 @default.
• W2017998911 hasConcept C2778151854 @default.
• W2017998911 hasConcept C2779306644 @default.

• next