FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017999639> ?p ?o ?g. }

• W2017999639 endingPage "333" @default.
• W2017999639 startingPage "326" @default.
• W2017999639 abstract "Splanchnic ischemia is common in critically ill patients, and it can result in injury not only of the intestine but also in distant organs, particularly in the lung. Local inflammatory changes play a pivotal role in the development of acute lung injury after intestinal ischemia, but the underlying molecular mechanisms are not fully understood. We sought to examine the role of Toll-like receptor 4 (TLR4) in the mouse model of intestinal ischemia-reperfusion (I/R)-induced lung injury and inflammation.Adult male TLR4 mutant (C3H/HeJ) mice and TLR4 wild-type (WT) (C3H/HeOuJ) mice were subjected to 40 min of intestinal ischemia by clamping the superior mesenteric artery followed by 6 h of reperfusion. Lung histology was assessed and parameters of pulmonary microvascular permeability, inflammatory cytokine expression, and neutrophil infiltration were measured. Activation of mitogen-activated protein kinases (MAPKs) and the transcription factors nuclear factor κB (NF-κB) and activator protein-1 (AP-1) in the lungs were also detected.After intestinal I/R, lungs from TLR4 mutant mice demonstrated a significantly lower histological injury, a marked reduction of epithelial apoptosis associated with the decreased level of cleaved caspase-3 and the increased ratio of Bcl-xL to Bax proteins, and a large reduction in pulmonary vascular permeability and myeloperoxidase (MPO) activity in comparison with WT mice. TLR4 mutant mice also displayed marked decreases in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2) expression. Following intestinal I/R, phosporylation of p38 MAPK and activation of NF-κB and AP-1 were significantly inhibited in lung tissue from TLR4 mutant mice compared with WT controls.These data suggest that TLR4 plays an important role in the pathogenesis of intestinal I/R-induced acute lung injury and inflammation and that p38 kinase and NF-κB may be involved in TLR4 signaling-mediated lung inflammatory processes during intestinal I/R." @default.
• W2017999639 created "2016-06-24" @default.
• W2017999639 creator A5005567886 @default.
• W2017999639 creator A5025629839 @default.
• W2017999639 creator A5026528466 @default.
• W2017999639 creator A5041044588 @default.
• W2017999639 creator A5050471394 @default.
• W2017999639 creator A5082328023 @default.
• W2017999639 creator A5087194864 @default.
• W2017999639 date "2012-05-01" @default.
• W2017999639 modified "2023-10-16" @default.
• W2017999639 title "TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion" @default.
• W2017999639 cites W1531708526 @default.
• W2017999639 cites W1938040121 @default.
• W2017999639 cites W1981815493 @default.
• W2017999639 cites W1993426158 @default.
• W2017999639 cites W1999064607 @default.
• W2017999639 cites W2010660431 @default.
• W2017999639 cites W2023381249 @default.
• W2017999639 cites W2038566124 @default.
• W2017999639 cites W2044934919 @default.
• W2017999639 cites W2049927679 @default.
• W2017999639 cites W2056056200 @default.
• W2017999639 cites W2057336764 @default.
• W2017999639 cites W2064235229 @default.
• W2017999639 cites W2068854215 @default.
• W2017999639 cites W2071303972 @default.
• W2017999639 cites W2071383186 @default.
• W2017999639 cites W2073704190 @default.
• W2017999639 cites W2079879922 @default.
• W2017999639 cites W2085910914 @default.
• W2017999639 cites W2106516898 @default.
• W2017999639 cites W2110444443 @default.
• W2017999639 cites W2163280564 @default.
• W2017999639 cites W2194006659 @default.
• W2017999639 doi "https://doi.org/10.1016/j.jss.2010.12.005" @default.
• W2017999639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21392794" @default.
• W2017999639 hasPublicationYear "2012" @default.
• W2017999639 type Work @default.
• W2017999639 sameAs 2017999639 @default.
• W2017999639 citedByCount "81" @default.
• W2017999639 countsByYear W20179996392012 @default.
• W2017999639 countsByYear W20179996392013 @default.
• W2017999639 countsByYear W20179996392014 @default.
• W2017999639 countsByYear W20179996392015 @default.
• W2017999639 countsByYear W20179996392016 @default.
• W2017999639 countsByYear W20179996392017 @default.
• W2017999639 countsByYear W20179996392018 @default.
• W2017999639 countsByYear W20179996392019 @default.
• W2017999639 countsByYear W20179996392020 @default.
• W2017999639 countsByYear W20179996392021 @default.
• W2017999639 countsByYear W20179996392022 @default.
• W2017999639 countsByYear W20179996392023 @default.
• W2017999639 crossrefType "journal-article" @default.
• W2017999639 hasAuthorship W2017999639A5005567886 @default.
• W2017999639 hasAuthorship W2017999639A5025629839 @default.
• W2017999639 hasAuthorship W2017999639A5026528466 @default.
• W2017999639 hasAuthorship W2017999639A5041044588 @default.
• W2017999639 hasAuthorship W2017999639A5050471394 @default.
• W2017999639 hasAuthorship W2017999639A5082328023 @default.
• W2017999639 hasAuthorship W2017999639A5087194864 @default.
• W2017999639 hasConcept C126322002 @default.
• W2017999639 hasConcept C142724271 @default.
• W2017999639 hasConcept C17991360 @default.
• W2017999639 hasConcept C203014093 @default.
• W2017999639 hasConcept C203565725 @default.
• W2017999639 hasConcept C2776070231 @default.
• W2017999639 hasConcept C2776914184 @default.
• W2017999639 hasConcept C2777714996 @default.
• W2017999639 hasConcept C2780114680 @default.
• W2017999639 hasConcept C541997718 @default.
• W2017999639 hasConcept C71924100 @default.
• W2017999639 hasConceptScore W2017999639C126322002 @default.
• W2017999639 hasConceptScore W2017999639C142724271 @default.
• W2017999639 hasConceptScore W2017999639C17991360 @default.
• W2017999639 hasConceptScore W2017999639C203014093 @default.
• W2017999639 hasConceptScore W2017999639C203565725 @default.
• W2017999639 hasConceptScore W2017999639C2776070231 @default.
• W2017999639 hasConceptScore W2017999639C2776914184 @default.
• W2017999639 hasConceptScore W2017999639C2777714996 @default.
• W2017999639 hasConceptScore W2017999639C2780114680 @default.
• W2017999639 hasConceptScore W2017999639C541997718 @default.
• W2017999639 hasConceptScore W2017999639C71924100 @default.
• W2017999639 hasFunder F4320321001 @default.
• W2017999639 hasIssue "2" @default.
• W2017999639 hasLocation W20179996391 @default.
• W2017999639 hasLocation W20179996392 @default.
• W2017999639 hasOpenAccess W2017999639 @default.
• W2017999639 hasPrimaryLocation W20179996391 @default.
• W2017999639 hasRelatedWork W1975240939 @default.
• W2017999639 hasRelatedWork W1997810015 @default.
• W2017999639 hasRelatedWork W2073328546 @default.
• W2017999639 hasRelatedWork W2091299039 @default.
• W2017999639 hasRelatedWork W2347831388 @default.
• W2017999639 hasRelatedWork W2349746825 @default.
• W2017999639 hasRelatedWork W2356822645 @default.
• W2017999639 hasRelatedWork W2371656075 @default.
• W2017999639 hasRelatedWork W2393304049 @default.

• next