FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017999874> ?p ?o ?g. }

• W2017999874 endingPage "157" @default.
• W2017999874 startingPage "147" @default.
• W2017999874 abstract "SAP-1 is a 113 amino acid long single-chain protein which belongs to the type 2 cystatin gene family. In our previous study, we have purified SAP-1 from human seminal plasma and observed its cross-class inhibitory property. At this time, we report the interaction of SAP-1 with diverse proteases and its binding partners by CD-spectroscopic and molecular docking methods. The circular dichroism (CD) spectroscopic studies demonstrate that the conformation of SAP-1 is changed after its complexation with proteases, and the alterations in protein secondary structure are quantitatively calculated with increase of α-helices and reduction of β-strand content. To get insight into the interactions between SAP-1 and proteases, we make an effort to model the three-dimensional structure of SAP-1 by molecular modeling and verify its stability and viability through molecular dynamics simulations and finally complexed with different proteases using ClusPro 2.0 Server. A high degree of shape complementarity is examined within the complexes, stabilized by a number of hydrogen bonds (HBs) and hydrophobic interactions. Using HB analyses in different protein complexes, we have identified a series of key residues that may be involved in the interactions between SAP-1 and proteases. These findings will assist to understand the mechanism of inhibition of SAP-1 for different proteases and provide intimation for further research." @default.
• W2017999874 created "2016-06-24" @default.
• W2017999874 creator A5035054695 @default.
• W2017999874 creator A5055332029 @default.
• W2017999874 creator A5067013633 @default.
• W2017999874 creator A5075869401 @default.
• W2017999874 creator A5087664464 @default.
• W2017999874 date "2013-11-21" @default.
• W2017999874 modified "2023-10-18" @default.
• W2017999874 title "Studies on the interactions of SAP-1 (an N-terminal truncated form of cystatin S) with its binding partners by CD-spectroscopic and molecular docking methods" @default.
• W2017999874 cites W1593567129 @default.
• W2017999874 cites W1617965928 @default.
• W2017999874 cites W1794799782 @default.
• W2017999874 cites W1966319203 @default.
• W2017999874 cites W1978592925 @default.
• W2017999874 cites W1981021420 @default.
• W2017999874 cites W1986191025 @default.
• W2017999874 cites W1988771356 @default.
• W2017999874 cites W2002598174 @default.
• W2017999874 cites W2008353150 @default.
• W2017999874 cites W2008708467 @default.
• W2017999874 cites W2034286345 @default.
• W2017999874 cites W2035266068 @default.
• W2017999874 cites W2041905742 @default.
• W2017999874 cites W2042272007 @default.
• W2017999874 cites W2058569149 @default.
• W2017999874 cites W2071486470 @default.
• W2017999874 cites W2077595384 @default.
• W2017999874 cites W2077776336 @default.
• W2017999874 cites W2090638587 @default.
• W2017999874 cites W2094316817 @default.
• W2017999874 cites W2097546936 @default.
• W2017999874 cites W2102312699 @default.
• W2017999874 cites W2102993309 @default.
• W2017999874 cites W2103945336 @default.
• W2017999874 cites W2104246038 @default.
• W2017999874 cites W2105213795 @default.
• W2017999874 cites W2113623846 @default.
• W2017999874 cites W2128572087 @default.
• W2017999874 cites W2130606742 @default.
• W2017999874 cites W2131900949 @default.
• W2017999874 cites W2132670203 @default.
• W2017999874 cites W2136832587 @default.
• W2017999874 cites W2147421370 @default.
• W2017999874 cites W2158783623 @default.
• W2017999874 cites W2162166182 @default.
• W2017999874 cites W2168480638 @default.
• W2017999874 cites W2171268876 @default.
• W2017999874 cites W4236236547 @default.
• W2017999874 cites W95014119 @default.
• W2017999874 doi "https://doi.org/10.1080/07391102.2013.855882" @default.
• W2017999874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24261636" @default.
• W2017999874 hasPublicationYear "2013" @default.
• W2017999874 type Work @default.
• W2017999874 sameAs 2017999874 @default.
• W2017999874 citedByCount "2" @default.
• W2017999874 countsByYear W20179998742014 @default.
• W2017999874 countsByYear W20179998742017 @default.
• W2017999874 crossrefType "journal-article" @default.
• W2017999874 hasAuthorship W2017999874A5035054695 @default.
• W2017999874 hasAuthorship W2017999874A5055332029 @default.
• W2017999874 hasAuthorship W2017999874A5067013633 @default.
• W2017999874 hasAuthorship W2017999874A5075869401 @default.
• W2017999874 hasAuthorship W2017999874A5087664464 @default.
• W2017999874 hasBestOaLocation W20179998742 @default.
• W2017999874 hasConcept C102658986 @default.
• W2017999874 hasConcept C104317684 @default.
• W2017999874 hasConcept C112887158 @default.
• W2017999874 hasConcept C12554922 @default.
• W2017999874 hasConcept C133571119 @default.
• W2017999874 hasConcept C147597530 @default.
• W2017999874 hasConcept C159110408 @default.
• W2017999874 hasConcept C159641895 @default.
• W2017999874 hasConcept C178790620 @default.
• W2017999874 hasConcept C181199279 @default.
• W2017999874 hasConcept C182220744 @default.
• W2017999874 hasConcept C185592680 @default.
• W2017999874 hasConcept C25602115 @default.
• W2017999874 hasConcept C2776414213 @default.
• W2017999874 hasConcept C2776714187 @default.
• W2017999874 hasConcept C2778965386 @default.
• W2017999874 hasConcept C2779548226 @default.
• W2017999874 hasConcept C2780412452 @default.
• W2017999874 hasConcept C32909587 @default.
• W2017999874 hasConcept C41685203 @default.
• W2017999874 hasConcept C55493867 @default.
• W2017999874 hasConcept C59593255 @default.
• W2017999874 hasConcept C71240020 @default.
• W2017999874 hasConcept C71924100 @default.
• W2017999874 hasConcept C86803240 @default.
• W2017999874 hasConcept C90260826 @default.
• W2017999874 hasConceptScore W2017999874C102658986 @default.
• W2017999874 hasConceptScore W2017999874C104317684 @default.
• W2017999874 hasConceptScore W2017999874C112887158 @default.
• W2017999874 hasConceptScore W2017999874C12554922 @default.
• W2017999874 hasConceptScore W2017999874C133571119 @default.
• W2017999874 hasConceptScore W2017999874C147597530 @default.
• W2017999874 hasConceptScore W2017999874C159110408 @default.

• next