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- W2018001092 abstract "Our aim was to determine the molecular targets involved in the antiproliferative effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), in a normal murine mammary epithelial cell line, HC11. Among the early response genes analyzed, c-myc, junB, junD, c-jun, c-fos, fosB, fra, as well as max, mad1-4, sin3, only c-jun and fra-2 mRNAs were up-regulated after 1,25(OH)2D3 exposure. Cyclin C was reduced and cyclin A2 and E were slightly enhanced; however, cyclins D1, D3, B1, B2, F, G1, G2, I and H, as well as TGFβ1, TGFβ3, TβRI and TβRII transcripts were not modulated by 1,25(OH)2D3. Although p27KIP1 protein content was unchanged, enhancement of p21WAF1/CIP1 low basal levels in cell extracts and IGFBP-3 abundance on the culture medium was detected after 1,25(OH)2D3 induction. Using differential display analysis, we identified eight down-modulated clones in exposed cells: 26S proteasome non-ATPase subunit Pad1, ubiquitin-conjugating enzyme Ube2i, extracellular proteinase inhibitor Expi or Wdnm1, cytochrome-c oxidase Cox7c, microtubule-associated protein-1 light chain-3 (Map1lc3), nascent-associated complex alpha Naca, transforming acidic coiled-coil Tacc3, stearoyl-CoA desaturase (Scd), keratin 6α, and 1 up-regulated, fork head transcription factor Hfh-1L. Hence, the antiproliferative effect of 1,25(OH)2D3 seems associated to enhancement of c-jun, Fra-2, IGFBP3 and p21WAF1/CIP1. Decreased Pad1 and Ube2i might account for increased stability of cell cycle inhibitory proteins while reduced Wdnm1, Tacc3 and Scd might be secondary to accumulation of cells in G0/G1 phase." @default.
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- W2018001092 date "2003-01-01" @default.
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- W2018001092 title "Molecular targets of 1,25(OH)2D3 in HC11 normal mouse mammary cell line" @default.
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- W2018001092 doi "https://doi.org/10.1016/s0960-0760(03)00004-9" @default.
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