FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018004803> ?p ?o ?g. }

• W2018004803 endingPage "4173" @default.
• W2018004803 startingPage "4167" @default.
• W2018004803 abstract "gamma-Aminobutyric acid (GABA)ergic neurons terminating in the rostral hypothalamus are stimulated by testosterone. To investigate whether this action is mediated locally through androgen receptors in the rostral hypothalamus, bilateral microcannulas (28 gauge) containing the androgen receptor antagonist, hydroxyflutamide (HF), were stereotaxically implanted into the rostral medial preoptic area (rMPA) just dorsal to the major population of GnRH cell bodies. Two days later, blood samples were collected for assay of LH, and animals were killed for determination of GABAergic neuronal activity in tissue dissected from the site of the implanted cannulas. Animals were decapitated either without treatment or 60 min after inhibition of GABA degradation by aminooxyacetic acid (100 mg/kg, ip). The rate of GABA accumulation in the tissue after aminooxyacetic acid treatment was used as a measure of GABA turnover. Levels of messenger RNA for both forms of glutamic acid decarboxylase (GAD65 and GAD67), the rate-limiting enzyme responsible for GABA synthesis also were measured by a microlysate ribonuclease protection assay. LH levels were significantly increased (1.8-fold) in HF-treated animals compared with controls. In the MPA, beneath the implant cannulas, GABA turnover was significantly reduced in HF-treated rats. There was no effect of treatment in the frontal cortex, which was used as a control region. Surprisingly, levels of messenger RNA for both GAD65 and GAD67 were significantly increased in HF-treated rats. The results indicate that GABAergic neurons terminating in the rostral hypothalamus are tonically stimulated by testosterone acting by means of androgen receptors localized in this region. These findings support the working hypothesis that androgen-sensitive GABAergic neurons in the rMPA mediate the negative feedback action of testosterone on GnRH secretion in the male rat." @default.
• W2018004803 created "2016-06-24" @default.
• W2018004803 creator A5004385135 @default.
• W2018004803 creator A5006560578 @default.
• W2018004803 creator A5021512005 @default.
• W2018004803 creator A5028823192 @default.
• W2018004803 creator A5031501731 @default.
• W2018004803 date "1996-10-01" @default.
• W2018004803 modified "2023-10-11" @default.
• W2018004803 title "Antiandrogen microimplants into the rostral medial preoptic area decrease gamma-aminobutyric acidergic neuronal activity and increase luteinizing hormone secretion in the intact male rat." @default.
• W2018004803 cites W1472590375 @default.
• W2018004803 cites W1526596922 @default.
• W2018004803 cites W1536684227 @default.
• W2018004803 cites W1979065856 @default.
• W2018004803 cites W1981150989 @default.
• W2018004803 cites W1982681156 @default.
• W2018004803 cites W1990896300 @default.
• W2018004803 cites W1993856341 @default.
• W2018004803 cites W2003407316 @default.
• W2018004803 cites W2011294480 @default.
• W2018004803 cites W2011966632 @default.
• W2018004803 cites W2017067141 @default.
• W2018004803 cites W2019502456 @default.
• W2018004803 cites W2020000817 @default.
• W2018004803 cites W2023417087 @default.
• W2018004803 cites W2028951810 @default.
• W2018004803 cites W2031775588 @default.
• W2018004803 cites W2032603988 @default.
• W2018004803 cites W2041695054 @default.
• W2018004803 cites W204690133 @default.
• W2018004803 cites W2047250720 @default.
• W2018004803 cites W2052435478 @default.
• W2018004803 cites W2063524589 @default.
• W2018004803 cites W2064423783 @default.
• W2018004803 cites W2069001066 @default.
• W2018004803 cites W2075236615 @default.
• W2018004803 cites W2075847225 @default.
• W2018004803 cites W2077116771 @default.
• W2018004803 cites W2084892947 @default.
• W2018004803 cites W2089828703 @default.
• W2018004803 cites W2092949544 @default.
• W2018004803 cites W2094292417 @default.
• W2018004803 cites W2106510403 @default.
• W2018004803 cites W2108865171 @default.
• W2018004803 cites W2114366652 @default.
• W2018004803 cites W2117230181 @default.
• W2018004803 cites W2168901014 @default.
• W2018004803 cites W2263916484 @default.
• W2018004803 doi "https://doi.org/10.1210/endo.137.10.8828473" @default.
• W2018004803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8828473" @default.
• W2018004803 hasPublicationYear "1996" @default.
• W2018004803 type Work @default.
• W2018004803 sameAs 2018004803 @default.
• W2018004803 citedByCount "34" @default.
• W2018004803 countsByYear W20180048032014 @default.
• W2018004803 countsByYear W20180048032015 @default.
• W2018004803 countsByYear W20180048032016 @default.
• W2018004803 countsByYear W20180048032017 @default.
• W2018004803 countsByYear W20180048032021 @default.
• W2018004803 countsByYear W20180048032022 @default.
• W2018004803 crossrefType "journal-article" @default.
• W2018004803 hasAuthorship W2018004803A5004385135 @default.
• W2018004803 hasAuthorship W2018004803A5006560578 @default.
• W2018004803 hasAuthorship W2018004803A5021512005 @default.
• W2018004803 hasAuthorship W2018004803A5028823192 @default.
• W2018004803 hasAuthorship W2018004803A5031501731 @default.
• W2018004803 hasBestOaLocation W20180048031 @default.
• W2018004803 hasConcept C126322002 @default.
• W2018004803 hasConcept C134018914 @default.
• W2018004803 hasConcept C170493617 @default.
• W2018004803 hasConcept C17077164 @default.
• W2018004803 hasConcept C181199279 @default.
• W2018004803 hasConcept C185592680 @default.
• W2018004803 hasConcept C2776627618 @default.
• W2018004803 hasConcept C2777003273 @default.
• W2018004803 hasConcept C2777771985 @default.
• W2018004803 hasConcept C2777911890 @default.
• W2018004803 hasConcept C2778575703 @default.
• W2018004803 hasConcept C2779177108 @default.
• W2018004803 hasConcept C2908647359 @default.
• W2018004803 hasConcept C55493867 @default.
• W2018004803 hasConcept C71315377 @default.
• W2018004803 hasConcept C71924100 @default.
• W2018004803 hasConcept C86803240 @default.
• W2018004803 hasConcept C9497952 @default.
• W2018004803 hasConcept C99454951 @default.
• W2018004803 hasConceptScore W2018004803C126322002 @default.
• W2018004803 hasConceptScore W2018004803C134018914 @default.
• W2018004803 hasConceptScore W2018004803C170493617 @default.
• W2018004803 hasConceptScore W2018004803C17077164 @default.
• W2018004803 hasConceptScore W2018004803C181199279 @default.
• W2018004803 hasConceptScore W2018004803C185592680 @default.
• W2018004803 hasConceptScore W2018004803C2776627618 @default.
• W2018004803 hasConceptScore W2018004803C2777003273 @default.
• W2018004803 hasConceptScore W2018004803C2777771985 @default.
• W2018004803 hasConceptScore W2018004803C2777911890 @default.
• W2018004803 hasConceptScore W2018004803C2778575703 @default.
• W2018004803 hasConceptScore W2018004803C2779177108 @default.

• next