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- W2018006913 abstract "The degradation of 1% hydrocortisone in polyethylene glycol ointment USP was investigated. The stability tests were conducted on two different batches of ointments at 23, 45, and 60o for about 4 months. Decomposition occurred at the C-17 side chain as assayed by the blue tetrazolium reaction, as well as in ring A as determined by UV spectroscopy. The decomposition of the C-17 side chain was much faster (average half-life of 186 days at 60o) as compared with ring A (average half-life of 505 days at 60o). Decomposition of the C-17 chain appeared to be first order but was zero order for ring A. The energy of activation was determined to be 9.7 kcal/mole. Based on these studies, the shelflife for a 1% hydrocortisone ointment in polyethylene glycol base is suggested to be about 6 months. The shelflife may be extended to about 9 months with the addition of a 5% excess of the active ingredient at the time of manufacture." @default.
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- W2018006913 date "1974-01-01" @default.
- W2018006913 modified "2023-09-23" @default.
- W2018006913 title "Stability of Hydrocortisone in Polyethylene Glycol Ointment Base" @default.
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- W2018006913 doi "https://doi.org/10.1002/jps.2600630128" @default.
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