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- W2018009239 abstract "Abstract Purpose Testicular torsion/detorsion (T/D) RESULTS in enhanced formation of free radical species, which contribute to the pathophysiology of tissue damage. Numerous studies in recent years have shown protective effects of N-acetylcysteine (NAC) on cardiac and renal tissue damage following ischemia/reperfusion. We assessed the effectiveness of systemic administration of NAC – at therapeutic doses – in a rat model one-hour 720° testicular T/D. We chose the dose of NAC that reduced general ischemia/reperfusion syndrome in patients who had undergone abdominal aortic aneurysmectomy. Materials and Methods Sprague-Dawley rats were divided into 5 groups, 14 animals in each. Group 1 underwent sham operation as the control group. In group 2, rats underwent T/D and received vehicle injections. Animals in groups 3, 4 and 5 received intraperitoneal injections of 150 mg/kg NAC, 30 minutes before torsion, after torsion and after detorsion, respectively. Markers of oxidative stress as well as germ cell apoptosis indices were determined 4 and 24 hours after detorsion, respectively. Results Apoptosis indices were significantly higher in group 2 compared to control group. Four hours after detorsion, testicular level of lipid peroxidation was significantly increased and antioxidant enzymes activities were significantly decreased in group 2 in comparison with controls. Administration of NAC either 30 minutes before or after torsion (group 3 and 4), significantly improved the germ cell apoptosis indices and oxidant/antioxidant balance. Administration of NAC after detorsion had no significant effects on oxidant/antioxidant balance or germ cell apoptosis. Conclusions Administration of NAC prior to torsion or detorsion, but not after detorsion, is protective against ischemia/reperfusion tissue damage in the rat model of testicular torsion. Since NAC has an established safety after almost 40 years of clinical use as mucolytic agent and antidote of acetaminophen toxicity, one can suggest this agent as an adjunct therapy for “testicular torsion rescue”. Supplying intracellular glutathione as well as anti-oxidant and anti-inflammatory properties of NAC could be the possible mechanisms of this protective effect." @default.
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- W2018009239 date "2008-04-01" @default.
- W2018009239 modified "2023-09-23" @default.
- W2018009239 title "Administration of N-Acetylcysteine Reduces Germ Cell-Specific Apoptosis and Oxidative Injury Following Testicular Torsion in Rats" @default.
- W2018009239 doi "https://doi.org/10.1016/j.jpurol.2008.01.059" @default.
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