Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018010106> ?p ?o ?g. }
- W2018010106 endingPage "155" @default.
- W2018010106 startingPage "148" @default.
- W2018010106 abstract "The balance of reactive oxygen species (ROS) and nitric oxide, the cell redox state, appears to be important in the mechanisms of heart failure. This balance has significant impact on calcium-handling proteins, affecting excitation-contraction coupling. Both ROS and nitric oxide appear to be elevated in heart failure and are accompanied by significant impairments in the number and function of calcium-handling proteins. These proteins contain sulfhydryl groups or disulfide linkages involving cysteine residues, making them susceptible to the action of oxidizing-reducing agents and nitrosylation, thereby altering their properties. Initial increases in nitric oxide may be an adaptive response to myocardial dysfunction, elevated cytokines, and increases in ROS, while a further increase in nitric oxide and overwhelming ROS can be damaging. Abundant nitric oxide and ROS can cause formation of peroxynitrite, a strong oxidant, or nitric oxide can activate alternate pathways aiding the ROS, causing impaired calcium handling contributing to contractile dysfunction." @default.
- W2018010106 created "2016-06-24" @default.
- W2018010106 creator A5001634149 @default.
- W2018010106 creator A5006335310 @default.
- W2018010106 date "2002-05-01" @default.
- W2018010106 modified "2023-09-24" @default.
- W2018010106 title "Heart Failure, Oxidative Stress, and Ion Channel Modulation" @default.
- W2018010106 cites W1528657116 @default.
- W2018010106 cites W1531734841 @default.
- W2018010106 cites W1556814137 @default.
- W2018010106 cites W1571009912 @default.
- W2018010106 cites W1586179048 @default.
- W2018010106 cites W1899877571 @default.
- W2018010106 cites W1964767793 @default.
- W2018010106 cites W1967425951 @default.
- W2018010106 cites W1968133040 @default.
- W2018010106 cites W1972253696 @default.
- W2018010106 cites W1972488290 @default.
- W2018010106 cites W1973047758 @default.
- W2018010106 cites W1992127171 @default.
- W2018010106 cites W1997268902 @default.
- W2018010106 cites W1997403679 @default.
- W2018010106 cites W1997727911 @default.
- W2018010106 cites W1998489509 @default.
- W2018010106 cites W2005591501 @default.
- W2018010106 cites W2009292667 @default.
- W2018010106 cites W2011419396 @default.
- W2018010106 cites W2014843536 @default.
- W2018010106 cites W2014905160 @default.
- W2018010106 cites W2021159562 @default.
- W2018010106 cites W2023591835 @default.
- W2018010106 cites W2029665946 @default.
- W2018010106 cites W2031233485 @default.
- W2018010106 cites W2033594768 @default.
- W2018010106 cites W2036424054 @default.
- W2018010106 cites W2036718044 @default.
- W2018010106 cites W2037933176 @default.
- W2018010106 cites W2055033774 @default.
- W2018010106 cites W2058520514 @default.
- W2018010106 cites W2062502537 @default.
- W2018010106 cites W2069629971 @default.
- W2018010106 cites W2070504091 @default.
- W2018010106 cites W2071671407 @default.
- W2018010106 cites W2075133586 @default.
- W2018010106 cites W2077969074 @default.
- W2018010106 cites W2079417512 @default.
- W2018010106 cites W2079532357 @default.
- W2018010106 cites W2080892216 @default.
- W2018010106 cites W2088236700 @default.
- W2018010106 cites W2097268528 @default.
- W2018010106 cites W2098473142 @default.
- W2018010106 cites W2102564608 @default.
- W2018010106 cites W2102943923 @default.
- W2018010106 cites W2110361956 @default.
- W2018010106 cites W2112734792 @default.
- W2018010106 cites W2126308098 @default.
- W2018010106 cites W2127926880 @default.
- W2018010106 cites W2131549396 @default.
- W2018010106 cites W2140313980 @default.
- W2018010106 cites W2141663828 @default.
- W2018010106 cites W2143855170 @default.
- W2018010106 cites W2147602331 @default.
- W2018010106 cites W2147959747 @default.
- W2018010106 cites W2157109878 @default.
- W2018010106 cites W2158990159 @default.
- W2018010106 cites W2162092150 @default.
- W2018010106 cites W2164023695 @default.
- W2018010106 cites W2319084768 @default.
- W2018010106 cites W2337457656 @default.
- W2018010106 cites W4236653206 @default.
- W2018010106 cites W1979869140 @default.
- W2018010106 doi "https://doi.org/10.1111/j.1527-5299.2002.00716.x" @default.
- W2018010106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12045383" @default.
- W2018010106 hasPublicationYear "2002" @default.
- W2018010106 type Work @default.
- W2018010106 sameAs 2018010106 @default.
- W2018010106 citedByCount "63" @default.
- W2018010106 countsByYear W20180101062012 @default.
- W2018010106 countsByYear W20180101062013 @default.
- W2018010106 countsByYear W20180101062014 @default.
- W2018010106 countsByYear W20180101062015 @default.
- W2018010106 countsByYear W20180101062016 @default.
- W2018010106 countsByYear W20180101062018 @default.
- W2018010106 countsByYear W20180101062019 @default.
- W2018010106 countsByYear W20180101062020 @default.
- W2018010106 countsByYear W20180101062021 @default.
- W2018010106 countsByYear W20180101062022 @default.
- W2018010106 countsByYear W20180101062023 @default.
- W2018010106 crossrefType "journal-article" @default.
- W2018010106 hasAuthorship W2018010106A5001634149 @default.
- W2018010106 hasAuthorship W2018010106A5006335310 @default.
- W2018010106 hasConcept C12554922 @default.
- W2018010106 hasConcept C126322002 @default.
- W2018010106 hasConcept C181199279 @default.
- W2018010106 hasConcept C185592680 @default.
- W2018010106 hasConcept C2776151105 @default.
- W2018010106 hasConcept C2778198053 @default.
- W2018010106 hasConcept C2778784160 @default.