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- W2018010214 abstract "The effect of the phosphatase inhibitor calyculin A (cal A) on the kinetic parameters of the Na+-coupled taurine uptake via the taurine transporter in the Ehrlich ascites tumour cells has been investigated. Preincubation with cal A (100 nM) reduces the initial taurine influx by about 20%, but has no effect on the diffusional component of the taurine influx or on the taurine release from cells suspended in isotonic or in hypotonic medium. Thus, cal A-sensitive phosphatases only affect taurine transport mediated by the Na+-dependent taurine transporter. Cal A increases the Michaelis–Menten constant for binding of taurine to the transporter from 31±6 to 45±4 μM and reduces the taurine transport capacity from 210±20 to 170±10 pmol×g dry wt−1×min−1. The Michaelis–Menten constant for binding of Na+ to the taurine transporter is concomitantly increased from 96±11 to 129±8 mM and the Na+:taurine coupling ratio for activation of the transport cycle is reduced from 3.3±0.6 to 2.4±0.2. This suggests that cal A-sensitive phosphatases maintain a high affinity of the taurine transporter towards Na+ and taurine as well as a high taurine transport capacity in unpertubated Ehrlich cells." @default.
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- W2018010214 title "Calyculin A modulates the kinetic constants for the Na+-coupled taurine transport in Ehrlich ascites tumour cells" @default.
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- W2018010214 doi "https://doi.org/10.1016/s0005-2736(98)00033-9" @default.
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