FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018010977> ?p ?o ?g. }

• W2018010977 endingPage "e9522" @default.
• W2018010977 startingPage "e9522" @default.
• W2018010977 abstract "Yeast cells live in a highly fluctuating environment with respect to temperature, nutrients, and especially osmolarity. The Hog1 mitogen-activated protein kinase (MAPK) pathway is crucial for the adaption of yeast cells to external osmotic changes.To better understand the osmo-adaption mechanism in the budding yeast Saccharomyces cerevisiae, we have developed a mathematical model and quantitatively investigated the Hog1 response to osmotic stress. The model agrees well with various experimental data for the Hog1 response to different types of osmotic changes. Kinetic analyses of the model indicate that budding yeast cells have evolved to protect themselves economically: while they show almost no response to fast pulse-like changes of osmolarity, they respond periodically and are well-adapted to osmotic changes with a certain frequency. To quantify the signal transduction efficiency of the osmo-adaption network, we introduced a measure of the signal response gain, which is defined as the ratio of output change integral to input (signal) change integral. Model simulations indicate that the Hog1 response gain shows bell-shaped response curves with respect to the duration of a single osmotic pulse and to the frequency of periodic square osmotic pulses, while for up-staircase (ramp) osmotic changes, the gain depends on the slope.The model analyses suggest that budding yeast cells have selectively evolved to be optimized to some specific types of osmotic changes. In addition, our work implies that the signaling output can be dynamically controlled by fine-tuning the signal input profiles." @default.
• W2018010977 created "2016-06-24" @default.
• W2018010977 creator A5003799374 @default.
• W2018010977 creator A5046914403 @default.
• W2018010977 creator A5089948320 @default.
• W2018010977 date "2010-03-04" @default.
• W2018010977 modified "2023-10-14" @default.
• W2018010977 title "A Quantitative Study of the Hog1 MAPK Response to Fluctuating Osmotic Stress in Saccharomyces cerevisiae" @default.
• W2018010977 cites W1849061432 @default.
• W2018010977 cites W1898443428 @default.
• W2018010977 cites W1964513080 @default.
• W2018010977 cites W1970140396 @default.
• W2018010977 cites W1975351609 @default.
• W2018010977 cites W1981920890 @default.
• W2018010977 cites W1987315263 @default.
• W2018010977 cites W2011262079 @default.
• W2018010977 cites W2013947447 @default.
• W2018010977 cites W2023788610 @default.
• W2018010977 cites W2029086616 @default.
• W2018010977 cites W2040810566 @default.
• W2018010977 cites W2069405322 @default.
• W2018010977 cites W2087171152 @default.
• W2018010977 cites W2088127501 @default.
• W2018010977 cites W2105379381 @default.
• W2018010977 cites W2117994560 @default.
• W2018010977 cites W2122553662 @default.
• W2018010977 cites W2128782793 @default.
• W2018010977 cites W2128881595 @default.
• W2018010977 cites W2132507158 @default.
• W2018010977 cites W2133403209 @default.
• W2018010977 cites W2135330882 @default.
• W2018010977 cites W2144504620 @default.
• W2018010977 cites W2145871402 @default.
• W2018010977 cites W2150908245 @default.
• W2018010977 cites W2157479134 @default.
• W2018010977 cites W2158944498 @default.
• W2018010977 cites W2159100436 @default.
• W2018010977 cites W2171109336 @default.
• W2018010977 doi "https://doi.org/10.1371/journal.pone.0009522" @default.
• W2018010977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2831999" @default.
• W2018010977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20209100" @default.
• W2018010977 hasPublicationYear "2010" @default.
• W2018010977 type Work @default.
• W2018010977 sameAs 2018010977 @default.
• W2018010977 citedByCount "68" @default.
• W2018010977 countsByYear W20180109772012 @default.
• W2018010977 countsByYear W20180109772013 @default.
• W2018010977 countsByYear W20180109772014 @default.
• W2018010977 countsByYear W20180109772015 @default.
• W2018010977 countsByYear W20180109772016 @default.
• W2018010977 countsByYear W20180109772017 @default.
• W2018010977 countsByYear W20180109772018 @default.
• W2018010977 countsByYear W20180109772019 @default.
• W2018010977 countsByYear W20180109772020 @default.
• W2018010977 countsByYear W20180109772021 @default.
• W2018010977 countsByYear W20180109772022 @default.
• W2018010977 countsByYear W20180109772023 @default.
• W2018010977 crossrefType "journal-article" @default.
• W2018010977 hasAuthorship W2018010977A5003799374 @default.
• W2018010977 hasAuthorship W2018010977A5046914403 @default.
• W2018010977 hasAuthorship W2018010977A5089948320 @default.
• W2018010977 hasBestOaLocation W20180109771 @default.
• W2018010977 hasConcept C104317684 @default.
• W2018010977 hasConcept C12554922 @default.
• W2018010977 hasConcept C129900496 @default.
• W2018010977 hasConcept C168529131 @default.
• W2018010977 hasConcept C186060115 @default.
• W2018010977 hasConcept C2777576037 @default.
• W2018010977 hasConcept C2779222958 @default.
• W2018010977 hasConcept C2992884146 @default.
• W2018010977 hasConcept C55493867 @default.
• W2018010977 hasConcept C57074206 @default.
• W2018010977 hasConcept C62478195 @default.
• W2018010977 hasConcept C86803240 @default.
• W2018010977 hasConcept C95444343 @default.
• W2018010977 hasConcept C9603476 @default.
• W2018010977 hasConceptScore W2018010977C104317684 @default.
• W2018010977 hasConceptScore W2018010977C12554922 @default.
• W2018010977 hasConceptScore W2018010977C129900496 @default.
• W2018010977 hasConceptScore W2018010977C168529131 @default.
• W2018010977 hasConceptScore W2018010977C186060115 @default.
• W2018010977 hasConceptScore W2018010977C2777576037 @default.
• W2018010977 hasConceptScore W2018010977C2779222958 @default.
• W2018010977 hasConceptScore W2018010977C2992884146 @default.
• W2018010977 hasConceptScore W2018010977C55493867 @default.
• W2018010977 hasConceptScore W2018010977C57074206 @default.
• W2018010977 hasConceptScore W2018010977C62478195 @default.
• W2018010977 hasConceptScore W2018010977C86803240 @default.
• W2018010977 hasConceptScore W2018010977C95444343 @default.
• W2018010977 hasConceptScore W2018010977C9603476 @default.
• W2018010977 hasIssue "3" @default.
• W2018010977 hasLocation W20180109771 @default.
• W2018010977 hasLocation W20180109772 @default.
• W2018010977 hasLocation W20180109773 @default.
• W2018010977 hasLocation W20180109774 @default.
• W2018010977 hasLocation W20180109775 @default.
• W2018010977 hasLocation W20180109776 @default.
• W2018010977 hasOpenAccess W2018010977 @default.

• next