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• W2018011312 abstract "Ex vivo {13C, 2H} NMR spectroscopy allowed to estimate the relative sizes of neuronal and glial glutamate pools and the relative contributions of (1-13C) glucose and (2-13C, 2-2H3) acetate to the neuronal and glial tricarboxylic acid cycles of the adult rat brain. Rats were infused during 60 min in the right jugular vein with solutions containing (2-13C, 2-2H3) acetate and (1-13C) glucose or (2-13C, 2-2H3) acetate only. At the end of the infusion the brains were frozen in situ and perchloric acid extracts were prepared and analyzed by high resolution 13C NMR spectroscopy (90.5 MHz). The relative sizes of the neuronal and glial glutamate pools and the contributions of acetyl-CoA molecules derived from (2-13C, 2H3) acetate or (1-13C) glucose entering the tricarboxylic acid cycles of both compartments, could be determined by the analysis of 2H–13C multiplets and 2H induced isotopic shifts observed in the C4 carbon resonances of glutamate and glutamine. During the infusions with (2-13C, 2-2H3) acetate and (1-13C) glucose, the glial glutamate pool contributed 9% of total cerebral glutamate being derived from (2-13C, 2-2H3) acetyl-CoA (4%), (2-13C) acetyl-CoA (3%) and recycled (2-13C, 2-2H) acetyl-CoA (2%). The neuronal glutamate pool accounted for 91% of the total cerebral glutamate being mainly originated from (2-13C) acetyl-CoA (86%) and (2-13C, 2-2H) acetyl-CoA (5%). During the infusions of (2-13C, 2-2H3) acetate only, the glial glutamate pool contributed 73% of the cerebral glutamate, being derived from (2-13C, 2-2H3) acetyl-CoA (36%), (2-13C, 2-2H) acetyl-CoA (27%) and (2-13C) acetyl-CoA (10%). The neuronal pool contributed 27% of cerebral glutamate being formed from (2-13C) acetyl-CoA (11%) and recycled (2-13C, 2-2H) acetyl-CoA (16%). These results illustrate the potential of {13C, 2H} NMR spectroscopy as a novel approach to investigate substrate selection and metabolic compartmentation in the adult mammalian brain." @default.
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• W2018011312 title "Metabolism of (1-13C) glucose and (2-13C, 2-2H3) acetate in the neuronal and glial compartments of the adult rat brain as detected by {13C, 2H} NMR spectroscopy" @default.
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• W2018011312 doi "https://doi.org/10.1016/s0197-0186(00)00025-5" @default.
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