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• W2018012741 endingPage "137" @default.
• W2018012741 startingPage "133" @default.
• W2018012741 abstract "The crystal structures of two different cobalamin (vitamin B12)-binding riboswitches are determined; the structures reveal how cobalamin facilitates interdomain interactions to regulate gene expression. Small metabolites and ligands can affect gene expression by binding to a structured part of an RNA known as a riboswitch. Although the structures of many riboswitch receptor domains have been solved, the complete riboswitch structure with regulatory domain had not been determined. Robert Batey and colleagues have now solved the structure of two different cobalamin (vitamin B12) riboswitches that include the downstream regulatory domain. Ligand recognition occurs largely as a result of shape complementarity, rather than the more typical hydrogen bonding. Structures of riboswitch receptor domains bound to their effector have shown how messenger RNAs recognize diverse small molecules, but mechanistic details linking the structures to the regulation of gene expression remain elusive1,2. To address this, here we solve crystal structures of two different classes of cobalamin (vitamin B12)-binding riboswitches that include the structural switch of the downstream regulatory domain. These classes share a common cobalamin-binding core, but use distinct peripheral extensions to recognize different B12 derivatives. In each case, recognition is accomplished through shape complementarity between the RNA and cobalamin, with relatively few hydrogen bonding interactions that typically govern RNA–small molecule recognition. We show that a composite cobalamin–RNA scaffold stabilizes an unusual long-range intramolecular kissing-loop interaction that controls mRNA expression. This is the first, to our knowledge, riboswitch crystal structure detailing how the receptor and regulatory domains communicate in a ligand-dependent fashion to regulate mRNA expression." @default.
• W2018012741 created "2016-06-24" @default.
• W2018012741 creator A5004642468 @default.
• W2018012741 creator A5016027247 @default.
• W2018012741 creator A5065366604 @default.
• W2018012741 creator A5074049459 @default.
• W2018012741 date "2012-10-14" @default.
• W2018012741 modified "2023-10-16" @default.
• W2018012741 title "B12 cofactors directly stabilize an mRNA regulatory switch" @default.
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• W2018012741 doi "https://doi.org/10.1038/nature11607" @default.
• W2018012741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518761" @default.
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