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• W2018013006 abstract "1 We analysed the kinetics of coupling between cytoplasmic calcium ([Ca2+]i) and ciliary beat frequency (CBF) using simultaneous single cilium recording and single cell [Ca2+]i measurements from cultured ovine tracheal epithelial cells. 2 CBF and [Ca2+]i (indicated by fura-2) were measured at rest and in response to activation of the G-protein coupled M3 muscarinic receptor by 10 μM acetylcholine (ACh). 3 Fourier transform analysis of 3 s data segments of light intensity from phase-contrast microscopy showed no significant delay between changes in [Ca2+]i and CBF during a 2 min exposure to ACh and subsequent washout. 4 CBF time resolution was improved by computing instantaneous beat frequency. This revealed that CBF lagged the rapid increase in [Ca2+]i in response to ACh with a delay of less than 1 beat cycle (143 ms at 7 Hz). When CBF was estimated by an improved Fourier method, this delay was observed to be 70 ± 30 ms (mean ± s.e.m.; n= 20 cilia). During the slower return to baseline, a lag of 8 ± 3.2 s was observed, indicative of hysteresis. 5 While calmodulin inhibitors (calmidazolium and W-7; each n= 5) decreased baseline CBF by an average of 1.1 ± 0.1 Hz, they did not alter the kinetic relationship between [Ca2+]i and CBF. Similarly, phosphatase inhibitors (okadaic acid and cyclosporin A; each n= 5), changed neither baseline CBF nor the kinetic coupling between [Ca2+]i and CBF. 6 These data suggest that the timing of Ca2+ action on CBF in ovine airway epithelial cells, is unlikely to be determined by phosphorylation reactions involving calmodulin or kinase/phosphatase reactions. 7 A simple model for Ca2+ stimulation of CBF is presented. Fits of the model to the data suggest four or more Ca2+ ions bind cooperatively to speed up CBF." @default.
• W2018013006 created "2016-06-24" @default.
• W2018013006 creator A5020479008 @default.
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• W2018013006 date "1999-11-01" @default.
• W2018013006 modified "2023-10-14" @default.
• W2018013006 title "Mode of Ca²⁺ action on ciliary beat frequency in single ovine airway epithelial cells" @default.
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• W2018013006 doi "https://doi.org/10.1111/j.1469-7793.1999.00851.x" @default.
• W2018013006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269609" @default.
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