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- W2018013632 abstract "Rheumatoid arthritis (RA) has been associated with an altered TH 1 /TH2 balance. Here we present first results with a technique to quantitate stimulated TH1 and TH2 subsets in whole blood by means of cytofluorimetric detection of intracytoplasmic TH1 and TH2 cytokines. A group of 10 patients suffering from initial stages of RA exhibited a significantly reduced percentage of TH1 cells (11.0 ± 2.0%) in the peripheral blood as compared to 13 healthy, age matched controls (28.8 ± 2.0%). The TH2 response, as determined by intracellular expression of IL-4, remained unchanged. The data may indicate a defect in the THO-TH 1 differentiation or/and a selective trapping of TH1 cells into the affected joints." @default.
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- W2018013632 date "1999-06-01" @default.
- W2018013632 modified "2023-10-17" @default.
- W2018013632 title "Early Rheumatoid Arthritis is Associated with Diminished Numbers of TH 1 Cells in Stimulated Peripheral Blood" @default.
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- W2018013632 doi "https://doi.org/10.1016/s0171-2985(99)80077-1" @default.
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