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- W2018014669 abstract "To describe and discuss our experience with cystic fibrosis (CF) carrier testing in a donor egg program.Retrospective review.Community hospital-based assisted reproductive technology (ART) program.Forty anonymous white oocyte donor applicants.Testing with a DNA mutation analysis panel.Frequency of heterozygotes for CF mutation among the donor applicants and the likelihood of carriers and noncarriers being selected by recipients.Five of 40 egg donor applicants (12.5%) were found to be heterozygous for a CF mutation; 35 women (87.5%) tested negative. Two of the five CF carriers (40.0%) were selected by five recipient couples and underwent four donation cycles after the recipients' male partners tested negative. Twenty-nine of the 35 noncarrier donors (82.9%) were matched and underwent 81 egg donation cycles. The likelihood of being selected was lower for CF carriers than for noncarriers.Our experience strongly supports the recommendation of routine CF testing of prospective white egg donors. Whereas heterozygosity lowers the probability of a donor being matched, it need not exclude her from the donor pool provided the recipient's partner is not a carrier. Empowering recipients to choose their own donors, focused patient education, and genetic counseling with precise determination of residual risk are important prerequisites for inclusion of CF carriers." @default.
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- W2018014669 title "Inclusion of heterozygotes for cystic fibrosis in the egg donor pool" @default.
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- W2018014669 doi "https://doi.org/10.1016/s0015-0282(02)03248-x" @default.
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