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• W2018015093 startingPage "151" @default.
• W2018015093 abstract "We have investigated the role of intracellular Ca2+in the opening of capacitative Ca2+entry (CCE) channels formed with rat TRP4 (rTRP4) using Xenopus oocytes. In rTRP4-expressing oocytes pretreated with thapsigargin, perfusion with A23187, a Ca2+ionophore, significantly potentiated the delayed phase of the CCE-mediated Cl–current response evoked by extracellular perfusion with Ca2+, without affecting the transient phase of CCE response. In control oocytes, the potentiation of delayed CCE response by A23187 was not significant. Using cut-open recording in combination with artificial intracellular perfusion of oocytes, CCE-mediated Cl–response was recorded at controlled cytosolic Ca2+concentrations. Intracellular perfusion with a Ca2+-free solution containing 10 mM EGTA abolished most of the CCE responses of both non-injected and rTRP4-expressing oocytes. The native CCE response was not fully recovered by subsequent increases in the intracellular Ca2+concentration up to 300 nM. However, CCE response of the rTRP4-expressing oocytes was restored at an internal Ca2+concentration of 110 nM. Blockade of endogenous Cl–channels with anion channel blocker isolated Ca2+current flowing through CCE channels and clarified the difference in the sensitivity to an internal Ca2+concentration. These findings indicate that recombinant CCE channels formed with rTRP4 are positively regulated by cytosolic Ca2+at higher sensitivity compared to oocyte-endogenous CCE channels." @default.
• W2018015093 created "2016-06-24" @default.
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• W2018015093 date "2000-09-01" @default.
• W2018015093 modified "2023-09-27" @default.
• W2018015093 title "Positive regulation of capacitative Ca2+entry by intracellular Ca2+in Xenopus oocytes expressing rat TRP4" @default.
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• W2018015093 doi "https://doi.org/10.1054/ceca.2000.0143" @default.
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