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- W2018016797 abstract "The discovery of new signalling pathways is always followed by the development of pharmacological agents as drugs that can be used in the treatment of diseases resulting from a dysfunction of the signalling pathway in question. Apelin signalling plays a role in the central and peripheral regulation of the cardiovascular system, in water and food intake, and possibly in immune function. Up-regulation of ligand and receptor is also associated with pathophysiological states such as cardiac dysfunction and neovascularisation. Finally, the apelin receptor is a coreceptor for the entry of several HIV-1 and SIV strains. In view of these features, the apelin receptor constitutes a very interesting target for the design of new drugs for treating the prime causes of human mortality." @default.
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- W2018016797 date "2005-04-01" @default.
- W2018016797 modified "2023-09-26" @default.
- W2018016797 title "Apelin signalling: a promising pathway from cloning to pharmacology" @default.
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- W2018016797 doi "https://doi.org/10.1016/j.cellsig.2004.09.018" @default.
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