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- W2018016847 abstract "705 Living donor (LD) kidney transplantation continues to increase due to the shortage of cadaver donors. The increase of LD is in part due to the use of donors that may have previously been excluded, including the elderly (Eld), hypertensive (HTN) or both. There is little data regarding the long-term outcome in these suboptimal donors and it may not be ethical to prospectively study these LD. To help answer this question, we retrospectively studied the records of 104 patients undergoing uninephrectomy (UNx) for a renal maligancy between 3/9/88 and 7/5/96. Mean followup was 751days ± 542 (182-2090). 50 patients had>6 month followup and included male=29/female21, white=44/black6, age 57 ± 13(23-79). The group was divided into: I)age<50, no HTN (controls, C), n=10 II)age>60, no HTN (Elderly, E), n=11 III)age<60+HTN (Ht), n=14 IV)age>60+HTN (EHt), n=10. Ht/EHt had HTN for avg. of 14 and 18 yrs and were on 1.1 and 2.0 BP meds respectively. Weight, BP, serum creatinine (Cr) and urinalysis for protein were examined prior to UNx (pre) and at followup (post). Cr clearance (CrCl) was estimated by Cockcroft-Gault and mean arterial pressure (MAP) was derived from measured BP. TableThe decline in CrCl was similar in all groups but the% decline was higher in EldHt (p>0.05). There was no increase in proteinuria after UNx. Conclusion: Renal function after UNx in pts <age 60 with controlled HTN results in substantial decline in renal function. The effect of HTN appears additive to the that of aging and the combination, EHt, results in significant renal deterioration. This information may be useful when considering certain LD especially if long-term studies confirm these data." @default.
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- W2018016847 date "1998-05-01" @default.
- W2018016847 modified "2023-10-17" @default.
- W2018016847 title "RENAL FUNCTION AFTER NEPHRECTOMY IN THE ELDERLY AND HYPERTENSIVE: IMPLICATIONS FOR LIVING DONORS" @default.
- W2018016847 doi "https://doi.org/10.1097/00007890-199805131-00701" @default.
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