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• W2018017811 abstract "Macromolecular drug forms are expected to prolong the drug residence time in the compartment of application due to their very limited passage across compartmental barriers. Second, the carrier may protect the active moiety from inactivation and may render it less immunogenic. Third, the macromolecular carrier provides the opportunity of attaching specific ligands with tissue or organ affinity which makes the control of drug biodistribution possible. Similar to many natural regulatory macromolecules, the onset of function is contingent on the cleavage of the drug-carrier bond. Any carrier polymers should be cleared from the body after fulfilment of its role, the safest way being degradation to metabolizable fragments. Most macromolecular drugs are processed in lysosomes, but drug release in the central compartment would be more favourable in some cases. It is necessary to check the degradation of the final drug form and assess the pharmacology and immunology of all intermediate fragments. Certain fragments may play an important role in biodistribution and antigen presentation. Some synthetic polymers are known as biodegradable in the environment, but their biodegradability in the body has never been checked and is doubtful. It is difficult to shape natural macromolecules to the needs of pharmacology; the future lies therefore in synthetic polymers degradable in the main chain, poly(amino acids) being the most promising type." @default.
• W2018017811 created "2016-06-24" @default.
• W2018017811 creator A5049120956 @default.
• W2018017811 date "1989-03-01" @default.
• W2018017811 modified "2023-10-17" @default.
• W2018017811 title "Biodegradable soluble macromolecules as drug carriers" @default.
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• W2018017811 doi "https://doi.org/10.1016/0169-409x(89)90012-4" @default.
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