FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018019307> ?p ?o ?g. }

• W2018019307 endingPage "744" @default.
• W2018019307 startingPage "737" @default.
• W2018019307 abstract "Gemcitabine is an anticancer agent rapidly deaminated to the inactive metabolite 2‘,2‘-difluorodeoxyuridine. Its stability as well as bioavailability can be increased by making prodrugs. A series of lipophilic prodrugs of gemcitabine were synthesized by linking the 4-amino group with valeroyl, lauroyl, and stearoyl linear acyl derivatives. We studied, by the differential scanning calorimetry technique, and compared the interaction of pure gemcitabine and its prodrugs with dimyristoylphosphatidylcholine and distearoylphosphatidylcholine vesicles with the aim of demonstrating if the gemcitabine prodrug is more able than the pure gemcitabine to interact with lipid vesicles employed both as model biomembranes and as carriers in the transport of antitumor drugs. These studies, carried out by static and kinetic calorimetric measurements, give evidence that the increase of the prodrug's lipophilic character improves the interaction with lipid bilayers, favoring the absorption through the lipid barriers and allowing the liposomes to work (when the prodrug is inserted inside the vesicles) as a lipophilic carrier which is able to deliver the drug near the cell surface. The use of different prodrugs modified in their lipophilic character, of different kinds of vesicles (multilamellar and unilamellar), and of different kinds of vesicles forming phospholipids permitted us to determine the better equilibrium between in-vesicle solubility and through-vesicle diffusion of the drug, important in the preformulative studies of antitumor carriers based on phospholipid formulations. Such studies suggest that the prodrug lipophilic tail should modulate the transport and the release of gemcitabine inside the cellular compartments, and the efficiency of the liposomal system is related to the length of the prodrug's acyl chain which has to match the phospholipid acyl chain allowing or retarding the migration through the lipid release device. Keywords: Gemcitabine; lipophilic gemcitabine derivatives; liposomes; pharmacokinetics; calorimetry" @default.
• W2018019307 created "2016-06-24" @default.
• W2018019307 creator A5001339286 @default.
• W2018019307 creator A5014337097 @default.
• W2018019307 creator A5036607687 @default.
• W2018019307 creator A5049703091 @default.
• W2018019307 creator A5059574925 @default.
• W2018019307 date "2006-10-25" @default.
• W2018019307 modified "2023-10-16" @default.
• W2018019307 title "Characterization of Lipophilic Gemcitabine Prodrug−Liposomal Membrane Interaction by Differential Scanning Calorimetry" @default.
• W2018019307 cites W1970746557 @default.
• W2018019307 cites W1979480664 @default.
• W2018019307 cites W1979863624 @default.
• W2018019307 cites W1982507788 @default.
• W2018019307 cites W1986516374 @default.
• W2018019307 cites W1988531962 @default.
• W2018019307 cites W2003709444 @default.
• W2018019307 cites W2016953654 @default.
• W2018019307 cites W20305632 @default.
• W2018019307 cites W2035937863 @default.
• W2018019307 cites W2073816348 @default.
• W2018019307 cites W2083258595 @default.
• W2018019307 cites W2085016383 @default.
• W2018019307 cites W2093656664 @default.
• W2018019307 cites W2125429310 @default.
• W2018019307 cites W2127024723 @default.
• W2018019307 cites W2132397321 @default.
• W2018019307 cites W2139578776 @default.
• W2018019307 doi "https://doi.org/10.1021/mp060059y" @default.
• W2018019307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17140261" @default.
• W2018019307 hasPublicationYear "2006" @default.
• W2018019307 type Work @default.
• W2018019307 sameAs 2018019307 @default.
• W2018019307 citedByCount "47" @default.
• W2018019307 countsByYear W20180193072012 @default.
• W2018019307 countsByYear W20180193072013 @default.
• W2018019307 countsByYear W20180193072014 @default.
• W2018019307 countsByYear W20180193072015 @default.
• W2018019307 countsByYear W20180193072016 @default.
• W2018019307 countsByYear W20180193072017 @default.
• W2018019307 countsByYear W20180193072018 @default.
• W2018019307 countsByYear W20180193072019 @default.
• W2018019307 countsByYear W20180193072020 @default.
• W2018019307 countsByYear W20180193072021 @default.
• W2018019307 crossrefType "journal-article" @default.
• W2018019307 hasAuthorship W2018019307A5001339286 @default.
• W2018019307 hasAuthorship W2018019307A5014337097 @default.
• W2018019307 hasAuthorship W2018019307A5036607687 @default.
• W2018019307 hasAuthorship W2018019307A5049703091 @default.
• W2018019307 hasAuthorship W2018019307A5059574925 @default.
• W2018019307 hasBestOaLocation W20180193072 @default.
• W2018019307 hasConcept C108215921 @default.
• W2018019307 hasConcept C121332964 @default.
• W2018019307 hasConcept C12554922 @default.
• W2018019307 hasConcept C130316041 @default.
• W2018019307 hasConcept C185154212 @default.
• W2018019307 hasConcept C185592680 @default.
• W2018019307 hasConcept C2776694085 @default.
• W2018019307 hasConcept C2778918659 @default.
• W2018019307 hasConcept C2780258809 @default.
• W2018019307 hasConcept C39519442 @default.
• W2018019307 hasConcept C39944091 @default.
• W2018019307 hasConcept C41625074 @default.
• W2018019307 hasConcept C54355233 @default.
• W2018019307 hasConcept C55493867 @default.
• W2018019307 hasConcept C86803240 @default.
• W2018019307 hasConcept C97355855 @default.
• W2018019307 hasConceptScore W2018019307C108215921 @default.
• W2018019307 hasConceptScore W2018019307C121332964 @default.
• W2018019307 hasConceptScore W2018019307C12554922 @default.
• W2018019307 hasConceptScore W2018019307C130316041 @default.
• W2018019307 hasConceptScore W2018019307C185154212 @default.
• W2018019307 hasConceptScore W2018019307C185592680 @default.
• W2018019307 hasConceptScore W2018019307C2776694085 @default.
• W2018019307 hasConceptScore W2018019307C2778918659 @default.
• W2018019307 hasConceptScore W2018019307C2780258809 @default.
• W2018019307 hasConceptScore W2018019307C39519442 @default.
• W2018019307 hasConceptScore W2018019307C39944091 @default.
• W2018019307 hasConceptScore W2018019307C41625074 @default.
• W2018019307 hasConceptScore W2018019307C54355233 @default.
• W2018019307 hasConceptScore W2018019307C55493867 @default.
• W2018019307 hasConceptScore W2018019307C86803240 @default.
• W2018019307 hasConceptScore W2018019307C97355855 @default.
• W2018019307 hasIssue "6" @default.
• W2018019307 hasLocation W20180193071 @default.
• W2018019307 hasLocation W20180193072 @default.
• W2018019307 hasLocation W20180193073 @default.
• W2018019307 hasOpenAccess W2018019307 @default.
• W2018019307 hasPrimaryLocation W20180193071 @default.
• W2018019307 hasRelatedWork W2003731969 @default.
• W2018019307 hasRelatedWork W2009157011 @default.
• W2018019307 hasRelatedWork W2009857196 @default.
• W2018019307 hasRelatedWork W2011851765 @default.
• W2018019307 hasRelatedWork W2017142036 @default.
• W2018019307 hasRelatedWork W2080078119 @default.
• W2018019307 hasRelatedWork W2118940674 @default.
• W2018019307 hasRelatedWork W2135497551 @default.
• W2018019307 hasRelatedWork W2371186119 @default.

• next