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• W2018021875 abstract "La gaine conjonctive du ganglion sympathique cervical (30% du poids total du ganglion) n'est pas un obstacle, in vitroàla diffusion des gaz, des substrats et des métabolites: il n'y a en effet pas de différence significative entre la durée de la transmission synaptique in vitro de ganglions dégainés ou intacts. La production de lactate par un ganglion dégainén'est pas significativement différente de celle du ganglion homologue non dégainé, compte tenu de la masse du tissu conjonctif. L'élévation du pH augmente la production du lactate. L'augmentation de la [HCO3−] agit dans le meˆme sens. Si le pH est modifiépar variation de la [HCO3−] l'effet est additif. En revanche les variations de la PCO2 ne semblent pas jouer un roˆle par elles-meˆmes. La conduction nerveuse n'est pas influencée dans les limites des variations du pH, de la PCO2 et des [HCO3−], utilisées dans cetteétude. La transmission synaptique n'est influencée ni par le pH, ni par la PCO2 dans les conditionsétudiées. En revanche une diminution de la [HCO3−] en-dessous de 8,09 m M entraîne une lésion synaptique irréversible. Dans les conditions oùla production de lactate est fortement abaissée la perte de la transmission synaptique est la plus précoce. Réciproquement cette fonction se maintient plus longtemps lorsque la production de lactate estélevée. Aerobic glycolysis always occurs in nervous tissue in vitro. This particular behaviour has been studied by measuring the lactate production of sympathetic ganglia isolated from the rat and incubated in oxygenated Krebs solution. The pH of this solution can be modified by changing either the concentration of the bicarbonate or the PCO2. When both are raised or lowered together one can study the effects of various concentrations of these components at a constant pH. In each of the conditions studied, the function of the tissue could be tested by stimulating the preganglionic nerve and recording the evoked electrophysiological response either on the pre- or the post-ganglionic nerves. The sheath of connecting tissue surrounding the ganglion represents about 1/3 of the total weight; nevertheless it does not constitute an important obstacle to diffusion of substrates or lactate: indeed the lactate output of a ganglion without its connective sheath was not significantly different from that of its paired sheathed ganglion, after correction had been made for the weight. The lactate production could be increased by raising the pH or by increasing the concentration of bicarbonate (at a constant pH, maintained by increasing the PCO2). Thus, altering the pH by a given amount caused a greater change in lactate production when mediated by [HCO3−] alterations than by changes in the PCO2. The greatest effect was observed on the lactate production when both pH and bicarbonate concentration were modified. On the other hand the lactate production was not much altered by changing the PCO2. Conduction in the preganglionic nerve was not altered within the limits of changes in pH, PCO2 and [HCO3−] studied in this paper. Synaptic transmission was not modified either by changes in pH or PCO2, but a decrease in the bicarbonate concentration to below 8.09 m M caused an irreversible synaptic lesion. In all conditions where lactate production was low, synaptic transmission consistently failed before minimal levels of lactate production were reached. Conversely, the synaptic transmission was maintained as long as the lactate production continued at its highest rate." @default.
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• W2018021875 date "1970-02-01" @default.
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• W2018021875 title "Effect des variations de la PCO2, du ph et de la [HCO3−] sur la production de lactate et la transmission synaptique du ganglion sympathique cervical isolédu rat" @default.
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• W2018021875 doi "https://doi.org/10.1016/0006-8993(70)90452-x" @default.
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