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- W2018030972 abstract "Sprague-Dawley rats were injected with 2-amino-1,3,4-thiadiazole (ATDA), 100 mg/kg ip, on one of days 10–14 of pregnancy (sperm day = day 0). A supplementary ip injection of nicotinamide (N), 100 mg/kg, was administered to some rats immediately after the ATDA injection on day 12. Embryonic deaths, reduction limb malformations, and depressed fetal weights were attributable to ATDA treatment, but N coadministration was protective. Fetuses from rats dosed with ATDA or ATDA+N on day 12 were recovered on day 18 or 19 and their skeletons stained with methylene blue. Abnormal cartilaginous continuities or “fusions” between the various cartilage skeletal elements were present in 99% of limbs in the ATDA-treated group. Extent of the fusions varied widely. In the forelimb, fusions occurred only in the carpus and paw, whereas in the hindlimb, there were many abnormal fusions of the tibia and fibula in addition to the fusions in the tarsus and paw. Cotreatment with N prevented fusions. Other rats treated on day 12 were sacrificed 4, 10, 24, 48, and 72 hours later. Embryonic limbs were cultured in vitro for two hours in a medium containing 3H-thymidine or 14C-leucine. Isotope incorporation was determined. Ten hours after treatment with ATDA, DNA synthesis was depressed to 1.2%–5.1% of control levels. By 72 hours, the rate of synthesis returned to normal. N coadministration was protective against the ATDA-induced depression of DNA synthesis at 10 hours. Some changes in the rate of protein synthesis after ATDA treatment were apparent." @default.
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- W2018030972 title "A study of cartilaginous fusions, DNA synthesis, and protein synthesis in embryonic rat limbs after injection of aminothiadiazole" @default.
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- W2018030972 doi "https://doi.org/10.1002/tera.1420210316" @default.
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