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• W2018032989 endingPage "127" @default.
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• W2018032989 abstract "Purpose To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma. Design Analytical nonexperimental study of published peer-reviewed data. Methods Literature search and analysis of pertinent articles published between January 1, 1980 and June 30, 2008. Results Of 80 identified publications, 12 (15.0%) were review articles without original information, 2 (2.5%) were review articles combined with case reports, 22 (27.5%) were case reports, 16 (20.0%) were retrospective descriptive case series reports, 3 (3.75%) were pilot studies of a novel intervention, 2 (2.5%) were prospective phase I clinical trials, 8 (10.0%) were prospective phase I/II clinical trials, and 15 (18.75%) were prospective phase II clinical trials. None of the articles reported a prospective, randomized phase III clinical trial. The largest reported unselected patient groups had a median survival of 3 to 4 months after detection of metastasis, whereas the largest selected patient groups showed substantially longer median survival times. Conclusions Although median survival time after diagnosis of metastatic uveal melanoma tends to be substantially longer in selected patient subgroups subjected to aggressive invasive interventions than it is in unselected groups, much if not most of this apparent difference in survival is likely to be attributable to selection bias, surveillance bias, and publication bias rather than treatment-induced alteration of expected outcome. Published peer-reviewed articles do not provide compelling scientific evidence of any survival benefit of any method of treatment for any subgroup of patients with metastatic uveal melanoma. To evaluate and comment on published peer-reviewed literature for evidence of effectiveness of treatments for metastatic uveal melanoma. Analytical nonexperimental study of published peer-reviewed data. Literature search and analysis of pertinent articles published between January 1, 1980 and June 30, 2008. Of 80 identified publications, 12 (15.0%) were review articles without original information, 2 (2.5%) were review articles combined with case reports, 22 (27.5%) were case reports, 16 (20.0%) were retrospective descriptive case series reports, 3 (3.75%) were pilot studies of a novel intervention, 2 (2.5%) were prospective phase I clinical trials, 8 (10.0%) were prospective phase I/II clinical trials, and 15 (18.75%) were prospective phase II clinical trials. None of the articles reported a prospective, randomized phase III clinical trial. The largest reported unselected patient groups had a median survival of 3 to 4 months after detection of metastasis, whereas the largest selected patient groups showed substantially longer median survival times. Although median survival time after diagnosis of metastatic uveal melanoma tends to be substantially longer in selected patient subgroups subjected to aggressive invasive interventions than it is in unselected groups, much if not most of this apparent difference in survival is likely to be attributable to selection bias, surveillance bias, and publication bias rather than treatment-induced alteration of expected outcome. Published peer-reviewed articles do not provide compelling scientific evidence of any survival benefit of any method of treatment for any subgroup of patients with metastatic uveal melanoma." @default.
• W2018032989 created "2016-06-24" @default.
• W2018032989 creator A5022465976 @default.
• W2018032989 creator A5048368548 @default.
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• W2018032989 date "2009-07-01" @default.
• W2018032989 modified "2023-10-17" @default.
• W2018032989 title "Effectiveness of Treatments for Metastatic Uveal Melanoma" @default.
• W2018032989 cites W1923481401 @default.
• W2018032989 cites W1927638035 @default.
• W2018032989 cites W1963855279 @default.
• W2018032989 cites W1971366285 @default.
• W2018032989 cites W1972151214 @default.
• W2018032989 cites W1972481630 @default.
• W2018032989 cites W1974575665 @default.
• W2018032989 cites W1975909997 @default.
• W2018032989 cites W1977239706 @default.
• W2018032989 cites W1980768164 @default.
• W2018032989 cites W1981745249 @default.
• W2018032989 cites W1988660804 @default.
• W2018032989 cites W1990287784 @default.
• W2018032989 cites W1991933930 @default.
• W2018032989 cites W1996683829 @default.
• W2018032989 cites W2003241627 @default.
• W2018032989 cites W2003446651 @default.
• W2018032989 cites W2011832231 @default.
• W2018032989 cites W2012040296 @default.
• W2018032989 cites W2013944616 @default.
• W2018032989 cites W2014120362 @default.
• W2018032989 cites W2014344989 @default.
• W2018032989 cites W2015563766 @default.
• W2018032989 cites W2023267864 @default.
• W2018032989 cites W2026849088 @default.
• W2018032989 cites W2029163009 @default.
• W2018032989 cites W2029247510 @default.
• W2018032989 cites W2030929275 @default.
• W2018032989 cites W204046373 @default.
• W2018032989 cites W2040577381 @default.
• W2018032989 cites W2042674992 @default.
• W2018032989 cites W2042919532 @default.
• W2018032989 cites W2043004945 @default.
• W2018032989 cites W2046078271 @default.
• W2018032989 cites W2046407629 @default.
• W2018032989 cites W2049482322 @default.
• W2018032989 cites W2051472988 @default.
• W2018032989 cites W2059001486 @default.
• W2018032989 cites W2068179289 @default.
• W2018032989 cites W2069230086 @default.
• W2018032989 cites W2071703736 @default.
• W2018032989 cites W2071791404 @default.
• W2018032989 cites W2077491499 @default.
• W2018032989 cites W2080831579 @default.
• W2018032989 cites W2081392142 @default.
• W2018032989 cites W2082626444 @default.
• W2018032989 cites W2085793960 @default.
• W2018032989 cites W2089251040 @default.
• W2018032989 cites W2089374430 @default.
• W2018032989 cites W2090065323 @default.
• W2018032989 cites W2096196853 @default.
• W2018032989 cites W2107726411 @default.
• W2018032989 cites W2110920908 @default.
• W2018032989 cites W2112188049 @default.
• W2018032989 cites W2139771875 @default.
• W2018032989 cites W2140033254 @default.
• W2018032989 cites W2153642831 @default.
• W2018032989 cites W2164569272 @default.
• W2018032989 cites W2165377165 @default.
• W2018032989 cites W2165636771 @default.
• W2018032989 cites W2166771927 @default.
• W2018032989 cites W2168736300 @default.
• W2018032989 cites W2170033239 @default.
• W2018032989 cites W2261379582 @default.
• W2018032989 cites W2322769373 @default.
• W2018032989 cites W2333225131 @default.
• W2018032989 cites W2334064776 @default.
• W2018032989 cites W2335875120 @default.
• W2018032989 cites W2416818602 @default.
• W2018032989 cites W300298480 @default.
• W2018032989 cites W58534140 @default.
• W2018032989 cites W65135050 @default.
• W2018032989 cites W82195015 @default.
• W2018032989 doi "https://doi.org/10.1016/j.ajo.2009.01.023" @default.
• W2018032989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19375060" @default.
• W2018032989 hasPublicationYear "2009" @default.
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