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- W2018040634 abstract "IT HAS been shown previously that the administration of ACTH to patients in doses muchsmaller than those commonly employed intravenously gives full therapeutic results withoutundesirable side reactions (1). The hormone was given as a continuous intravenous infusion, as suggested by Ingle (2), Gordon (3), Renold et al. (4), Mandel et al. (5) and Jellife et al. (6). In this paper a comparison has been made of the accepted criteria of adrenocortical activity in 21 patients receiving low and high dosages of ACTH. It was found that daily doses of 5 mg. or less by continuous intravenous infusion were therapeutically effective and physiologic in action. Twenty-one hospitalized patients (Table 1 and Figs. 1 and 2) suffering from diseases usually responding to ACTH therapy were studied. There were 12 cases of rheumatoid arthritis, 5 of bronchial asthma, 2 of rheumatic fever, 1 of ulcerative colitis and 1 of polyarteritis nodosa. Cases #1–13 received 1 to 5 mg. of ACTH daily, and Cases #14–21 received 6 to 20 mg. daily. The ACTH (ACTHAR, Armour) was administered by continuous intravenous infusion in from 500 to 1000 ml. of a solution of 5 per cent glucose. The rate of the drip was 12 to 16 drops per minute. If a tendency to clotting was observed at the site of the venepuncture, 3 to 4 drops of a 1 per cent solution of heparin were added to the infusion." @default.
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- W2018040634 date "1954-04-01" @default.
- W2018040634 modified "2023-09-25" @default.
- W2018040634 title "CONTINUOUS INTRAVENOUS ACTH INFUSION IN SMALL DOSES AS A PHYSIOLOGIC APPROACH TO TREATMENT" @default.
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- W2018040634 doi "https://doi.org/10.1210/jcem-14-4-440" @default.
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