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• W2018043144 abstract "Exposure of ICR 2A frog cells to 265 nm, 289 nm, 302 nm or 313 nm monochromatic ultraviolet (UV) wavelengths induced the formation of sister-chromatid exchanges (SCEs). However, treatment of cells with photoreactivating light (PRL) following the UV irradiations resulted in a lower level of SCEs compared with cells incubated in the dark. Hence, it can be concluded that pyrimidine dimers are the principal photoproducts responsible for the induction of SCEs in cells exposed to 265–313 nm UV due to the specificity of DNA photolyase for the light-dependent monomerization of dimers in DNA. It was also found that the maximum yield of induced SCEs in 313 nm-irradiated cells was only about 7 SCEs per cell whereas the plateau values for the shorter wavelengths were approximately 15–20 SCEs per cell. In addition, treatment of cells with 313 nm plus 265 nm light resulted in a lower level of SCEs than in cells exposed to 265 nm UV alone. These results can be interpreted in the contextof a replication model for SCE, in which the high level of non-dimer damages produced in the DNA of 313 nm-irradiated cells inhibits the induction of SCEs by the pyrimidine dimers that are also produced by this wavelength." @default.
• W2018043144 created "2016-06-24" @default.
• W2018043144 creator A5033261943 @default.
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• W2018043144 date "1985-05-01" @default.
• W2018043144 modified "2023-09-27" @default.
• W2018043144 title "Induction of sister-chromatid exchanges in ICR 2A frog cells exposed to 265–313 nm monochromatic ultraviolet wavelengths and photoreactivating light" @default.
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• W2018043144 doi "https://doi.org/10.1016/0027-5107(85)90162-9" @default.
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