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• W2018045181 abstract "Abstract: The effect of neuropeptide Y inhibition with α-trinositol on the cerebral blood flow autoregulation was studied in Wistar Kyoto rats. α-Trinositol was tested in two doses: one dose (5 mg kg-1 hr-1) selectively affecting neuropeptide Y and one higher dose (50 mg kg-1 hr-1) affecting both neuropeptide Y and the adrenergic response. The cerebral blood flow was measured with the intracarotid 133xenon injection method in halothane nitrous oxide-anaesthetized animals. Blood pressure was raised by norepinephrine infusion and lowered by controlled haemorrhage in separate groups of rats. In addition we examined the effect of α-trinositol on neuropeptide Y-induced contraction of cerebral vessels in vitro. The in vitro study demonstrated inhibition of neuropeptide Y-induced contraction with a α-trinositol dose selective of neuropeptide Y. The in vivo study demonstrated that cerebral blood flow autoregulation was preserved after both doses of α-trinositol. α-Trinositol in the low neuropeptide Y-selective dose (5 mg kg-1 hr-1) did not affect the blood pressure limits of cerebral blood flow autoregulation, but the higher dose (50 mg kg-1 hr-1) of α-trinositol shifted the upper blood pressure limit of cerebral blood flow autoregulation towards lower blood pressures, an effect probably due to inhibition of both the adrenergic and neuropeptide Y systems." @default.
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• W2018045181 date "1997-01-01" @default.
• W2018045181 modified "2023-10-18" @default.
• W2018045181 title "Differential Effects of Increasing Doses of α-Trinositol on Cerebral Blood Flow Autoregulation" @default.
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• W2018045181 doi "https://doi.org/10.1111/j.1600-0773.1997.tb00281.x" @default.
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