FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018045642> ?p ?o ?g. }

• W2018045642 abstract "Anionic polymer sodium carboxymethylcellulose (CELLOGEN® HP-HS and/or HP-12HS) was investigated for its ability to influence the release of three model drugs propranolol hydrochloride, theophylline and ibuprofen from polyethylene oxide (POLYOX™ WSR 1105 and/or Coagulant) hydrophilic matrices. For anionic ibuprofen and non-ionic theophylline, no unusual/unexpected release profiles were obtained from tablets containing a mixture of two polymers. However, for cationic propranolol HCl, a combination of polyethylene oxide (PEO) with sodium carboxymethylcellulose (NaCMC) produced a significantly slower drug release compared to the matrices with single polymers. The potential use of this synergistic interaction can be a design of new extended release pharmaceutical dosage forms with a more prolonged release (beyond 12 h) using lower polymer amount, which could be particularly beneficial for freely water-soluble drugs, preferably for once daily oral administration. In order to explain changes in the obtained drug release profiles, Fourier transform infrared absorption spectroscopy was performed. A possible explanation for the more prolonged propranolol HCl release from matrices based on both PEO and NaCMC may be due to a chemical bond (i.e. ionic/electrostatic intermolecular interaction) between amine group of the cationic drug and carboxyl group of the anionic polymer, leading to a formation of a new type/form of the active (i.e. salt) with sustained release pattern." @default.
• W2018045642 created "2016-06-24" @default.
• W2018045642 creator A5008810564 @default.
• W2018045642 creator A5023571572 @default.
• W2018045642 creator A5026372655 @default.
• W2018045642 creator A5033145243 @default.
• W2018045642 creator A5086246940 @default.
• W2018045642 creator A5090614750 @default.
• W2018045642 date "2011-06-28" @default.
• W2018045642 modified "2023-10-04" @default.
• W2018045642 title "The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices" @default.
• W2018045642 cites W1525957268 @default.
• W2018045642 cites W183342415 @default.
• W2018045642 cites W1973393008 @default.
• W2018045642 cites W197368718 @default.
• W2018045642 cites W1973780063 @default.
• W2018045642 cites W1979883851 @default.
• W2018045642 cites W1982786181 @default.
• W2018045642 cites W1983072437 @default.
• W2018045642 cites W1983473009 @default.
• W2018045642 cites W1985370231 @default.
• W2018045642 cites W1991274230 @default.
• W2018045642 cites W1997041234 @default.
• W2018045642 cites W2001320297 @default.
• W2018045642 cites W2001721028 @default.
• W2018045642 cites W2009841111 @default.
• W2018045642 cites W2014147046 @default.
• W2018045642 cites W2018371048 @default.
• W2018045642 cites W2024944556 @default.
• W2018045642 cites W2026966429 @default.
• W2018045642 cites W2027014308 @default.
• W2018045642 cites W2028032162 @default.
• W2018045642 cites W2033798101 @default.
• W2018045642 cites W2037066986 @default.
• W2018045642 cites W2039699933 @default.
• W2018045642 cites W2039752857 @default.
• W2018045642 cites W2066487146 @default.
• W2018045642 cites W2068493054 @default.
• W2018045642 cites W2069239280 @default.
• W2018045642 cites W2071462678 @default.
• W2018045642 cites W2084003965 @default.
• W2018045642 cites W2086130473 @default.
• W2018045642 cites W2088003941 @default.
• W2018045642 cites W2090525596 @default.
• W2018045642 cites W2093913942 @default.
• W2018045642 cites W2094781183 @default.
• W2018045642 cites W2108490598 @default.
• W2018045642 cites W2131246495 @default.
• W2018045642 cites W2139215769 @default.
• W2018045642 cites W2146145185 @default.
• W2018045642 cites W2151114776 @default.
• W2018045642 cites W2168331030 @default.
• W2018045642 doi "https://doi.org/10.1208/s12249-011-9648-4" @default.
• W2018045642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3167260" @default.
• W2018045642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21710334" @default.
• W2018045642 hasPublicationYear "2011" @default.
• W2018045642 type Work @default.
• W2018045642 sameAs 2018045642 @default.
• W2018045642 citedByCount "41" @default.
• W2018045642 countsByYear W20180456422013 @default.
• W2018045642 countsByYear W20180456422014 @default.
• W2018045642 countsByYear W20180456422015 @default.
• W2018045642 countsByYear W20180456422016 @default.
• W2018045642 countsByYear W20180456422017 @default.
• W2018045642 countsByYear W20180456422018 @default.
• W2018045642 countsByYear W20180456422019 @default.
• W2018045642 countsByYear W20180456422020 @default.
• W2018045642 countsByYear W20180456422021 @default.
• W2018045642 countsByYear W20180456422022 @default.
• W2018045642 countsByYear W20180456422023 @default.
• W2018045642 crossrefType "journal-article" @default.
• W2018045642 hasAuthorship W2018045642A5008810564 @default.
• W2018045642 hasAuthorship W2018045642A5023571572 @default.
• W2018045642 hasAuthorship W2018045642A5026372655 @default.
• W2018045642 hasAuthorship W2018045642A5033145243 @default.
• W2018045642 hasAuthorship W2018045642A5086246940 @default.
• W2018045642 hasAuthorship W2018045642A5090614750 @default.
• W2018045642 hasBestOaLocation W20180456422 @default.
• W2018045642 hasConcept C178790620 @default.
• W2018045642 hasConcept C183882617 @default.
• W2018045642 hasConcept C185592680 @default.
• W2018045642 hasConcept C2778095195 @default.
• W2018045642 hasConcept C43617362 @default.
• W2018045642 hasConcept C521977710 @default.
• W2018045642 hasConcept C71924100 @default.
• W2018045642 hasConcept C77281830 @default.
• W2018045642 hasConcept C98274493 @default.
• W2018045642 hasConceptScore W2018045642C178790620 @default.
• W2018045642 hasConceptScore W2018045642C183882617 @default.
• W2018045642 hasConceptScore W2018045642C185592680 @default.
• W2018045642 hasConceptScore W2018045642C2778095195 @default.
• W2018045642 hasConceptScore W2018045642C43617362 @default.
• W2018045642 hasConceptScore W2018045642C521977710 @default.
• W2018045642 hasConceptScore W2018045642C71924100 @default.
• W2018045642 hasConceptScore W2018045642C77281830 @default.
• W2018045642 hasConceptScore W2018045642C98274493 @default.
• W2018045642 hasIssue "3" @default.
• W2018045642 hasLocation W20180456421 @default.
• W2018045642 hasLocation W20180456422 @default.
• W2018045642 hasLocation W20180456423 @default.

• next