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- W2018049195 abstract "Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse or nail-restricted hyperpigmentation, palmoplantar erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly and Raynaud phenomenon. We report here the case of a patient who developed acral hyperpigmentation during treatment with tegafur." @default.
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- W2018049195 date "2011-09-30" @default.
- W2018049195 modified "2023-10-14" @default.
- W2018049195 title "Tegafur-induced acral hyperpigmentation" @default.
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- W2018049195 doi "https://doi.org/10.4081/dr.2011.e30" @default.
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