Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018049674> ?p ?o ?g. }
- W2018049674 endingPage "7229" @default.
- W2018049674 startingPage "7220" @default.
- W2018049674 abstract "A modular total synthesis of the potent V-ATPase inhibitors archazolid A and B is reported. The convergent preparation was accomplished by late-stage diversification of joint intermediates. Key synthetic steps involve asymmetric boron-mediated aldol reactions, two consecutive Still−Gennari olefinations to set the characteristic (Z,Z)-diene system, a Brown crotyboration, and a diastereoselective aldol condensation of highly elaborate intermediates. For macrocyclization, both an HWE reaction and a Heck coupling were successfully employed to close the 24-membered macrolactone. During the synthetic campaign, a generally useful protocol for an E-selective Heck reaction of nonactivated alkenes and a method for the direct nucleophilic displacement of the Abiko−Masamune auxiliary with sterically hindered nucleophiles were developed. The expedient and flexible strategy will enable further SAR studies of the archazolids and more detailed evaluations of target-inhibitor interactions." @default.
- W2018049674 created "2016-06-24" @default.
- W2018049674 creator A5027835055 @default.
- W2018049674 creator A5060925523 @default.
- W2018049674 creator A5070495054 @default.
- W2018049674 creator A5082026880 @default.
- W2018049674 creator A5089291540 @default.
- W2018049674 date "2009-09-09" @default.
- W2018049674 modified "2023-10-17" @default.
- W2018049674 title "Modular Total Synthesis of Archazolid A and B" @default.
- W2018049674 cites W1568169946 @default.
- W2018049674 cites W1890761020 @default.
- W2018049674 cites W1964732329 @default.
- W2018049674 cites W1966645336 @default.
- W2018049674 cites W1972471493 @default.
- W2018049674 cites W1974393417 @default.
- W2018049674 cites W1975580088 @default.
- W2018049674 cites W1976047686 @default.
- W2018049674 cites W1979032552 @default.
- W2018049674 cites W1986391256 @default.
- W2018049674 cites W1993800646 @default.
- W2018049674 cites W2005769968 @default.
- W2018049674 cites W2012523656 @default.
- W2018049674 cites W2031799240 @default.
- W2018049674 cites W2035874054 @default.
- W2018049674 cites W2036084232 @default.
- W2018049674 cites W2055927979 @default.
- W2018049674 cites W2056138506 @default.
- W2018049674 cites W2057196424 @default.
- W2018049674 cites W2058623521 @default.
- W2018049674 cites W2064584216 @default.
- W2018049674 cites W2069712590 @default.
- W2018049674 cites W2078394136 @default.
- W2018049674 cites W2080788358 @default.
- W2018049674 cites W2104196253 @default.
- W2018049674 cites W2111642738 @default.
- W2018049674 cites W2112822872 @default.
- W2018049674 cites W2137696481 @default.
- W2018049674 cites W2143257810 @default.
- W2018049674 cites W2144471788 @default.
- W2018049674 cites W2145798249 @default.
- W2018049674 cites W2147439752 @default.
- W2018049674 cites W2149501066 @default.
- W2018049674 cites W2156402993 @default.
- W2018049674 cites W2164858038 @default.
- W2018049674 cites W2170366703 @default.
- W2018049674 cites W2174015724 @default.
- W2018049674 cites W2258905878 @default.
- W2018049674 cites W2952646376 @default.
- W2018049674 cites W3145530580 @default.
- W2018049674 doi "https://doi.org/10.1021/jo901565n" @default.
- W2018049674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19739663" @default.
- W2018049674 hasPublicationYear "2009" @default.
- W2018049674 type Work @default.
- W2018049674 sameAs 2018049674 @default.
- W2018049674 citedByCount "69" @default.
- W2018049674 countsByYear W20180496742012 @default.
- W2018049674 countsByYear W20180496742013 @default.
- W2018049674 countsByYear W20180496742014 @default.
- W2018049674 countsByYear W20180496742015 @default.
- W2018049674 countsByYear W20180496742016 @default.
- W2018049674 countsByYear W20180496742017 @default.
- W2018049674 countsByYear W20180496742018 @default.
- W2018049674 countsByYear W20180496742020 @default.
- W2018049674 countsByYear W20180496742021 @default.
- W2018049674 countsByYear W20180496742022 @default.
- W2018049674 countsByYear W20180496742023 @default.
- W2018049674 crossrefType "journal-article" @default.
- W2018049674 hasAuthorship W2018049674A5027835055 @default.
- W2018049674 hasAuthorship W2018049674A5060925523 @default.
- W2018049674 hasAuthorship W2018049674A5070495054 @default.
- W2018049674 hasAuthorship W2018049674A5082026880 @default.
- W2018049674 hasAuthorship W2018049674A5089291540 @default.
- W2018049674 hasConcept C161790260 @default.
- W2018049674 hasConcept C168896768 @default.
- W2018049674 hasConcept C178790620 @default.
- W2018049674 hasConcept C178907741 @default.
- W2018049674 hasConcept C185592680 @default.
- W2018049674 hasConcept C18616679 @default.
- W2018049674 hasConcept C201194858 @default.
- W2018049674 hasConcept C21951064 @default.
- W2018049674 hasConcept C35753019 @default.
- W2018049674 hasConcept C502130503 @default.
- W2018049674 hasConcept C61156836 @default.
- W2018049674 hasConcept C71240020 @default.
- W2018049674 hasConceptScore W2018049674C161790260 @default.
- W2018049674 hasConceptScore W2018049674C168896768 @default.
- W2018049674 hasConceptScore W2018049674C178790620 @default.
- W2018049674 hasConceptScore W2018049674C178907741 @default.
- W2018049674 hasConceptScore W2018049674C185592680 @default.
- W2018049674 hasConceptScore W2018049674C18616679 @default.
- W2018049674 hasConceptScore W2018049674C201194858 @default.
- W2018049674 hasConceptScore W2018049674C21951064 @default.
- W2018049674 hasConceptScore W2018049674C35753019 @default.
- W2018049674 hasConceptScore W2018049674C502130503 @default.
- W2018049674 hasConceptScore W2018049674C61156836 @default.
- W2018049674 hasConceptScore W2018049674C71240020 @default.
- W2018049674 hasIssue "19" @default.