Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018055211> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2018055211 endingPage "5329" @default.
- W2018055211 startingPage "5321" @default.
- W2018055211 abstract "Previous investigations have found that visible-light (VL)-irradiated camphorquinone (CQ), in the presence of a tertiary amine (e.g., N,N-dimethyl-p-toluidine, DMT), generates reactive oxygen species and causes oxidative DNA damage in vitro. In this study, oxidative DNA damage produced by VL-irradiated CQ/DMT, in the presence and absence of antioxidants (glutathione, N-acetyl-L-cysteine (NAC), mannitol, vitamin C, and vitamin E), was measured by the conversion of PhiX-174 RF I supercoiled (SC) double-stranded plasmid DNA into open and linear forms. VL-irradiated CQ/DMT, lacking antioxidant, damaged 99.4 +/- 1% of the PhiX-174 RF I SC double-stranded plasmid DNA. Our results revealed that glutathione (10.0, 5.0, 2.5, 1.0, and 0.5 mm) and NAC (10.0, 5.0, and 2.5 mm) significantly (p < 0.02) reduced oxidative DNA damage produced by VL-irradiated CQ/DMT. Vitamin E, vitamin C, and mannitol were ineffective at reducing oxidative DNA damage produced by VL-irradiated CQ/DMT. Furthermore, vitamin E (10.0 and 5.0 mm) and vitamin C (10.0, 5.0, 2.5, 1.0, 0.5 mm) treatment significantly (p < 0.02) enhanced VL-irradiated CQ/DMT-induced oxidative DNA damage and caused significant (p < 0.001) DNA damage following VL-irradiation in the absence of CQ/DMT. As a result, future studies should evaluate whether glutathione and NAC effectively reduce or prevent oxidative damage induced by VL-irradiated CQ/DMT in vivo." @default.
- W2018055211 created "2016-06-24" @default.
- W2018055211 creator A5019483032 @default.
- W2018055211 creator A5025913916 @default.
- W2018055211 creator A5071770709 @default.
- W2018055211 date "2005-09-01" @default.
- W2018055211 modified "2023-10-16" @default.
- W2018055211 title "The effect of antioxidants on oxidative DNA damage induced by visible-light-irradiated camphorquinone/,-dimethyl--toluidine" @default.
- W2018055211 cites W1505154018 @default.
- W2018055211 cites W1527225097 @default.
- W2018055211 cites W1528606854 @default.
- W2018055211 cites W1575560358 @default.
- W2018055211 cites W1953644283 @default.
- W2018055211 cites W1966695504 @default.
- W2018055211 cites W1974565424 @default.
- W2018055211 cites W1989705838 @default.
- W2018055211 cites W1992431983 @default.
- W2018055211 cites W2001145805 @default.
- W2018055211 cites W2002508440 @default.
- W2018055211 cites W2003296927 @default.
- W2018055211 cites W2008484769 @default.
- W2018055211 cites W2017391462 @default.
- W2018055211 cites W2068863521 @default.
- W2018055211 cites W2070919873 @default.
- W2018055211 cites W2080994093 @default.
- W2018055211 cites W2093645580 @default.
- W2018055211 cites W2101537600 @default.
- W2018055211 cites W2123411694 @default.
- W2018055211 cites W2125446037 @default.
- W2018055211 cites W2131030226 @default.
- W2018055211 cites W2154473145 @default.
- W2018055211 doi "https://doi.org/10.1016/j.biomaterials.2005.01.068" @default.
- W2018055211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15814130" @default.
- W2018055211 hasPublicationYear "2005" @default.
- W2018055211 type Work @default.
- W2018055211 sameAs 2018055211 @default.
- W2018055211 citedByCount "26" @default.
- W2018055211 countsByYear W20180552112013 @default.
- W2018055211 countsByYear W20180552112014 @default.
- W2018055211 countsByYear W20180552112015 @default.
- W2018055211 countsByYear W20180552112016 @default.
- W2018055211 countsByYear W20180552112018 @default.
- W2018055211 countsByYear W20180552112019 @default.
- W2018055211 crossrefType "journal-article" @default.
- W2018055211 hasAuthorship W2018055211A5019483032 @default.
- W2018055211 hasAuthorship W2018055211A5025913916 @default.
- W2018055211 hasAuthorship W2018055211A5071770709 @default.
- W2018055211 hasConcept C143425029 @default.
- W2018055211 hasConcept C153911025 @default.
- W2018055211 hasConcept C181199279 @default.
- W2018055211 hasConcept C185592680 @default.
- W2018055211 hasConcept C2776151105 @default.
- W2018055211 hasConcept C2778004101 @default.
- W2018055211 hasConcept C2780022331 @default.
- W2018055211 hasConcept C48349386 @default.
- W2018055211 hasConcept C538909803 @default.
- W2018055211 hasConcept C552990157 @default.
- W2018055211 hasConcept C55493867 @default.
- W2018055211 hasConcept C57600042 @default.
- W2018055211 hasConcept C86803240 @default.
- W2018055211 hasConceptScore W2018055211C143425029 @default.
- W2018055211 hasConceptScore W2018055211C153911025 @default.
- W2018055211 hasConceptScore W2018055211C181199279 @default.
- W2018055211 hasConceptScore W2018055211C185592680 @default.
- W2018055211 hasConceptScore W2018055211C2776151105 @default.
- W2018055211 hasConceptScore W2018055211C2778004101 @default.
- W2018055211 hasConceptScore W2018055211C2780022331 @default.
- W2018055211 hasConceptScore W2018055211C48349386 @default.
- W2018055211 hasConceptScore W2018055211C538909803 @default.
- W2018055211 hasConceptScore W2018055211C552990157 @default.
- W2018055211 hasConceptScore W2018055211C55493867 @default.
- W2018055211 hasConceptScore W2018055211C57600042 @default.
- W2018055211 hasConceptScore W2018055211C86803240 @default.
- W2018055211 hasIssue "26" @default.
- W2018055211 hasLocation W20180552111 @default.
- W2018055211 hasLocation W20180552112 @default.
- W2018055211 hasOpenAccess W2018055211 @default.
- W2018055211 hasPrimaryLocation W20180552111 @default.
- W2018055211 hasRelatedWork W1490540217 @default.
- W2018055211 hasRelatedWork W1985087138 @default.
- W2018055211 hasRelatedWork W2313463101 @default.
- W2018055211 hasRelatedWork W2368772701 @default.
- W2018055211 hasRelatedWork W2765590223 @default.
- W2018055211 hasRelatedWork W2791181644 @default.
- W2018055211 hasRelatedWork W3082631906 @default.
- W2018055211 hasRelatedWork W3184501995 @default.
- W2018055211 hasRelatedWork W3197540311 @default.
- W2018055211 hasRelatedWork W99063305 @default.
- W2018055211 hasVolume "26" @default.
- W2018055211 isParatext "false" @default.
- W2018055211 isRetracted "false" @default.
- W2018055211 magId "2018055211" @default.
- W2018055211 workType "article" @default.