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- W2018056504 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILThe Sanger Institute in the UK has an ongoing initiative termed the “Cancer Genome Project” to systematically characterize the genetics and genomics of 770 cancer cell lines. Similarly, the Broad Institute in the US collaborates on the “Cancer Cell Line Encyclopedia” or CCLE project, entailing the eventual characterization of approximately 1000 cancer cell lines. At present, there are over 400 cell lines shared by these two initiatives. As part of a number of computational efforts in cancer biology we have used data from these two programs and have observed some unexpected differences in cell lines at the DNA and/or transcript level as well as some phenotypic differences, and we present here an analysis of these results including implications to the use of cancer cell lines in drug discovery and the larger question of genomic stability in cancer.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5109. doi:1538-7445.AM2012-5109" @default.
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- W2018056504 date "2012-04-15" @default.
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- W2018056504 title "Abstract 5109: Identical cancer cell lines from Sanger & Broad CCLE programs sometimes differ" @default.
- W2018056504 doi "https://doi.org/10.1158/1538-7445.am2012-5109" @default.
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