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- W2018058963 abstract "Low oxygen tension is a feature of many physiologic and pathologic conditions, including wound healing, fibrosis, and neoplasia. Increasing evidence suggests that low oxygen tension induces the transcription of a number of genes, and that this process depends on the cellular context. The proteins synthesized from these genes enable cells to adapt to the hypoxic environment and/or to fulfill their functional roles. The regulatory regions responsible for the induction of erythropoietin gene transcription and synthesis in response to hypoxia/anemia appear to be cis-acting deoxyribonucleic acid sequences located within the 5′ and 3′ flanking regions of the erythropoietin gene. Other proteins induced by hypoxia include cytokines (plateletderived growth factor-β chain, endothelin-1, transforming growth factor-β), enzymes (tyrosine hydroxylase, glycolytic enzymes), and stress proteins. The molecular mechanisms of the hypoxia-induced expression of these genes are poorly understood. A heme protein may act as the oxygen tension sensor, or the redox state of certain nuclear transcription factors may function as second messengers." @default.
- W2018058963 created "2016-06-24" @default.
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- W2018058963 date "1993-07-01" @default.
- W2018058963 modified "2023-10-17" @default.
- W2018058963 title "Gene Expression in Low Oxygen Tension" @default.
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- W2018058963 doi "https://doi.org/10.1097/00000441-199307000-00010" @default.
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