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- W201805979 abstract "Obesity is related to myocardial dysfunction and heart failure. We examined key proteins of cardiomyocyte metabolism in heart left ventricle from obese (OG) and control (CG) groups from adult mice (180 days) overfed during lactation. Hearts from both groups were also analyzed by the Langendorff System during Baseline (CGBL, OGBL) and Ischemia/Reperfusion (CGIR, OGIR) conditions. OG showed a significant increase in total body fat with a larger adipocytes area (p <0.0001). Heart mass and heart mass/body mass (p<0.0001) were also increased with increased cardiomyocytes area (p<0.001). Ghrelin receptor (GHS-R1a) content (p<0.02) and AKT expression and phosphorylation (p<0.03) was increased in the heart of OG. Hemodynamic showed higher EDP and Tau (relaxation time) in OGIR compared to BL (p<0.05); Max dp/dt lower in IR compared to BL (p<0.05); Min dp/dt lower in the CGIR and OGIR compared to OGBL (p<0.05). We conclude that overnutrition during lactation leads to obesity in adulthood, with myocardial remodeling, GHS-R1a and AKT phosphorylation content increasing associated to hemodynamic changes in the heart. Supported by CNPq (305903/2007); FAPERJ (E-26/110.578/2009)." @default.
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- W201805979 date "2011-04-01" @default.
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- W201805979 title "Ghrelin receptor and heart hemodynamic in obese adult mice overfed during lactation" @default.
- W201805979 doi "https://doi.org/10.1096/fasebj.25.1_supplement.1029.4" @default.
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