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• W2018060426 abstract "T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a small family of related proteins that regulate immune cell activities. TIM-1 was initially characterized in a mouse congenic analysis of Th2 T cell responses and related pathology. Data accumulated to date suggest that TIM-1 regulates effector T cell function, and may play distinct roles in the activities of B cells, invariant NKT cells and epithelial cells. In addition, a variety of ligands for TIM-1 have been proposed. In this review I discuss recent data that have accumulated on the function of TIM-1, propose a model to explain how TIM-1 regulates effector T cell activity through recognition of distinct ligands, and review others functions of this increasingly fascinating protein. Of considerable interest are the novel findings that TIM-1 mediates virus entry and virulence." @default.
• W2018060426 created "2016-06-24" @default.
• W2018060426 creator A5051450662 @default.
• W2018060426 date "2011-12-01" @default.
• W2018060426 modified "2023-09-26" @default.
• W2018060426 title "Novel roles for TIM-1 in immunity and infection" @default.
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• W2018060426 doi "https://doi.org/10.1016/j.imlet.2011.08.003" @default.
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