Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018068324> ?p ?o ?g. }
- W2018068324 abstract "Telomerase and the control of telomere length are intimately linked to the process of tumourigenesis in humans. Here I review the evidence that variation at the 5p15.33 locus, which contains the TERT gene (encoding the catalytic subunit of telomerase), might play a role in the determination of cancer risk. Mutations in the coding regions of TERT can affect telomerase activity and telomere length, and create severe clinical phenotypes, including bone marrow failure syndromes and a substantive increase in cancer frequency. Variants within the TERT gene have been associated with increased risk of haematological malignancies, including myelodysplastic syndrome and acute myeloid leukaemia as well as chronic lymphocytic leukaemia. Furthermore, there is good evidence from a number of independent genome-wide association studies to implicate variants at the 5p15.33 locus in cancer risk at several different sites: lung cancer, basal cell carcinoma and pancreatic cancer show strong associations, while bladder, prostate and cervical cancer and glioma also show risk alleles in this region. Thus, multiple independent lines of evidence have implicated variation in the TERT gene as a risk factor for cancer. The mechanistic basis of these risk variants is yet to be established; however, the basic biology suggests that telomere length control is a tantalising candidate mechanism underlying cancer risk." @default.
- W2018068324 created "2016-06-24" @default.
- W2018068324 creator A5043353019 @default.
- W2018068324 date "2010-05-01" @default.
- W2018068324 modified "2023-10-18" @default.
- W2018068324 title "Variation at the<i>TERT</i>locus and predisposition for cancer" @default.
- W2018068324 cites W146416921 @default.
- W2018068324 cites W1483245334 @default.
- W2018068324 cites W1484491723 @default.
- W2018068324 cites W1496836853 @default.
- W2018068324 cites W1516272650 @default.
- W2018068324 cites W1543500873 @default.
- W2018068324 cites W1575095130 @default.
- W2018068324 cites W1587107897 @default.
- W2018068324 cites W1600373583 @default.
- W2018068324 cites W1612842202 @default.
- W2018068324 cites W1676646253 @default.
- W2018068324 cites W1739103212 @default.
- W2018068324 cites W1927581912 @default.
- W2018068324 cites W1964977047 @default.
- W2018068324 cites W1965035358 @default.
- W2018068324 cites W1967511876 @default.
- W2018068324 cites W1968006026 @default.
- W2018068324 cites W1970891016 @default.
- W2018068324 cites W1972020976 @default.
- W2018068324 cites W1972202164 @default.
- W2018068324 cites W1973577066 @default.
- W2018068324 cites W1973637908 @default.
- W2018068324 cites W1975166737 @default.
- W2018068324 cites W1976273464 @default.
- W2018068324 cites W1979176867 @default.
- W2018068324 cites W1979496143 @default.
- W2018068324 cites W1979856750 @default.
- W2018068324 cites W1980554045 @default.
- W2018068324 cites W1981062788 @default.
- W2018068324 cites W1983138170 @default.
- W2018068324 cites W1983673827 @default.
- W2018068324 cites W1983856113 @default.
- W2018068324 cites W1983906638 @default.
- W2018068324 cites W1984280207 @default.
- W2018068324 cites W1985641439 @default.
- W2018068324 cites W1998760884 @default.
- W2018068324 cites W1999276461 @default.
- W2018068324 cites W1999872096 @default.
- W2018068324 cites W2001733842 @default.
- W2018068324 cites W2002429822 @default.
- W2018068324 cites W2003562932 @default.
- W2018068324 cites W2004208866 @default.
- W2018068324 cites W2005574136 @default.
- W2018068324 cites W2006948908 @default.
- W2018068324 cites W2007846880 @default.
- W2018068324 cites W2008887514 @default.
- W2018068324 cites W2012221707 @default.
- W2018068324 cites W2014414194 @default.
- W2018068324 cites W2014451495 @default.
- W2018068324 cites W2015889452 @default.
- W2018068324 cites W2017364257 @default.
- W2018068324 cites W2018882391 @default.
- W2018068324 cites W2021758398 @default.
- W2018068324 cites W2023026302 @default.
- W2018068324 cites W2023819485 @default.
- W2018068324 cites W2024209230 @default.
- W2018068324 cites W2024524259 @default.
- W2018068324 cites W2025843494 @default.
- W2018068324 cites W2027779909 @default.
- W2018068324 cites W2028639737 @default.
- W2018068324 cites W2032486291 @default.
- W2018068324 cites W2033535804 @default.
- W2018068324 cites W2034022379 @default.
- W2018068324 cites W2034631710 @default.
- W2018068324 cites W2034674816 @default.
- W2018068324 cites W2036307272 @default.
- W2018068324 cites W2036395225 @default.
- W2018068324 cites W2036698875 @default.
- W2018068324 cites W2037236933 @default.
- W2018068324 cites W2037891309 @default.
- W2018068324 cites W2039435758 @default.
- W2018068324 cites W2039709545 @default.
- W2018068324 cites W2040601774 @default.
- W2018068324 cites W2042000503 @default.
- W2018068324 cites W2043204829 @default.
- W2018068324 cites W2046268297 @default.
- W2018068324 cites W2047816315 @default.
- W2018068324 cites W2048662077 @default.
- W2018068324 cites W2049462421 @default.
- W2018068324 cites W2051916393 @default.
- W2018068324 cites W2053042580 @default.
- W2018068324 cites W2053300345 @default.
- W2018068324 cites W2053522504 @default.
- W2018068324 cites W2059383813 @default.
- W2018068324 cites W2063069674 @default.
- W2018068324 cites W2064144407 @default.
- W2018068324 cites W2064651531 @default.
- W2018068324 cites W2065841924 @default.
- W2018068324 cites W2068211792 @default.
- W2018068324 cites W2068409711 @default.
- W2018068324 cites W2069507654 @default.
- W2018068324 cites W2070823796 @default.
- W2018068324 cites W2071673220 @default.
- W2018068324 cites W2072221774 @default.