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- W2018068904 abstract "Xenopus embryos were exposed to valproate (0, 20, 40, 80 mg/l) either before or after neural tube closure. The embryos were then homogenized and fractionated by gel electrophoresis, and N-cadherin was detected and measured with quantitative immunoblotting. Findings indicated that valproate exposure increased N-cadherin production in a dose-dependent manner. Embryos exposed prior to neural tube closure tended to be more sensitive to the effects of valproate. These findings suggest that alterations in N-cadherin-mediated adhesion or morphogenesis may partially explain the teratogenic mechanism of valproate." @default.
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- W2018068904 date "2000-09-01" @default.
- W2018068904 modified "2023-10-14" @default.
- W2018068904 title "Valproate enhances N-cadherin production in Xenopus embryos" @default.
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- W2018068904 doi "https://doi.org/10.1016/s0892-0362(00)00086-6" @default.
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