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- W2018071102 abstract "RATIONALE: IL-21 is a γ-chain cytokine made exclusively by CD4+ T cells and acts almost on all immune cells. In the murine model, culture of DCs with IL-21 impaired their maturation. We investigated the influence of IL-21 on the maturation and function of human myeloid DCs in a standard culture system. METHODS: Monocyte derived dendritic cells were generated in GM-CSF and IL-4 with and without 20ng/mL IL-21 (designated as IL-21 DC and control DC) for 5 days and matured in TNF-α, IL1β and PGE2 for 2 days. DCs were phenotyped for expression of CD83, CD86, CD80, HLADR and CCR7. Proliferation and IFN-γ production by autologous T cells were evaluated after live flu infection of mature DCs. Capacity of DCs to secrete cytokine (TNF-α) after short-term stimulation with LPS was evaluated. RESULTS: In contrast to the report in mice, human IL-21DCs matured as well as control DCs with similar expression of maturation markers CD83, CCR7 and costimulatory molecules CD80 and CD86. T cells cultured with flu pulsed IL-21DCs exhibited a 2-fold increase in IFN-γ production and a 5-fold increase in proliferation compared to control DCs, indicating an augmentation in the antigen presentation by IL-21DCs. IL-21DCs (20, 50, 100ng/mL) were hyperresponsive to LPS as observed by the dose dependant increase in TNF-α secretion. CONCLUSIONS: DCs generated in presence of IL-21 mature normally, respond strongly to LPS and induce stronger T cell responses to flu virus infection. IL-21 augments myeloid DC function. The adjuvant activity of IL-21 in infectious and allergic diseases merits further investigation." @default.
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- W2018071102 date "2006-02-01" @default.
- W2018071102 modified "2023-10-18" @default.
- W2018071102 title "Il-21 Augments Function of Human Dendritic Cells" @default.
- W2018071102 doi "https://doi.org/10.1016/j.jaci.2005.12.067" @default.
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