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• W2018072656 startingPage "9" @default.
• W2018072656 abstract "Histamine, involved in many inflammatory reactions and immune responses, is reported to suppress—via H4R stimulation—injury concomitant with the late phase of warm hepatic ischemia/re-perfusion (I/R). The current study investigated the possible effects of histamine on the acute phase of hepatic I/R injury, and the possible underlying mechanisms like oxidative stress and release of inflammatory cytokines (e.g., tumor necrosis factor (TNF)-α nd interleukin [IL]-12). Rats were divided into naïve, sham-operated, and I/R groups. The I/R group was divided into sub-groups and pre-treated with histaminergic ligands before induction of ischemia. Anesthetized rats were subjected to warm ischemia for 30 min by occlusion of the portal vein and hepatic artery, then re-perfused for 90 min. Rats in the control I/R group showed significant increases in hepatic malondialdehyde (MDA), TNFα, and IL-12 contents, and in plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels, along with significant decreases in hepatic reduced glutathione (GSH) content and marked diffuse histopathologic damage. Pre-treatment with histamine resulted in significant mitigation of each of these end-points. The protective effect of histamine was not antagonized by pre-treatment with mepyramine (H1R antagonist) or ranitidine (H2R antagonist) and completely reversed by pre-treatment with thioperamide (H3R and H4R antagonist). In addition, the histamine protective effect was mimicked by pre-treatment of rats with clozapine (H4R agonist). These observations strongly suggested that histamine has a protective effect against hepatic I/R-mediated tissue injury during the acute phase, and this effect was mediated through an H4R stimulation that led to a decrease in IL-12 and TNFα production—outcomes that consequently decreased localized oxidative stress and afforded hepatic protection in general." @default.
• W2018072656 created "2016-06-24" @default.
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• W2018072656 date "2012-07-13" @default.
• W2018072656 modified "2023-09-23" @default.
• W2018072656 title "Histamine protects against the acute phase of experimentally-induced hepatic ischemia/re-perfusion" @default.
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• W2018072656 doi "https://doi.org/10.3109/1547691x.2012.684158" @default.
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