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• W2018073062 abstract "Elevated plasma concentrations of the cytokine tumor necrosis factor alpha (TNF alpha) have been observed in patients affected by leptospirosis. In this study we found that a preparation of peptidoglycan of Leptospira interrogans, serovar copenhageni, was able to induce the release of TNF alpha from peripheral blood mononuclear cells. TNF alpha induction occurred in a dose dependent manner and was not affected by the endotoxin inhibitor polymixin B. This is the first report on induction of TNF alpha release by a peptidoglycan of spirochetes. Our findings are consistent with existing clinical data and provide a potential mechanism for TNF alpha production." @default.
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• W2018073062 date "1996-05-01" @default.
• W2018073062 modified "2023-09-23" @default.
• W2018073062 title "<i>Leptospira interrogans</i>and<i>Leptospira</i>peptidoglycans induce the release of tumor necrosis factor a from human monocytes" @default.
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• W2018073062 doi "https://doi.org/10.1111/j.1574-6968.1996.tb08159.x" @default.
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