Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018076163> ?p ?o ?g. }
- W2018076163 endingPage "152" @default.
- W2018076163 startingPage "141" @default.
- W2018076163 abstract "Smad3 is one of the signal transducers that are activated in response to transforming growth factor-β (TGF-β). We have identified and characterized a splicing variant of smad3. The splicing variant (smad3-Δ3) lacks exon 3 resulting in a truncated linker region. We could detect mRNA expression of smad3-Δ3 in all investigated human tissues. Real-time PCR analyses demonstrated that the fraction of smad3-Δ3 mRNA compared to normal smad3 varies between tissues. The amount of spliced mRNA was estimated to represent 0.5–5% of the normal smad3 mRNA. When smad3-Δ3 is overexpressed in a fibrosarcoma cell line, the Smad3-Δ3 is translocated to the nucleus upon TGF-β stimulation and binds the Smad responsive element. Using a CAGA luciferase reporter system, we demonstrate that Smad3-Δ3 has transcriptional activity and we conclude that Smad3-Δ3 possesses functional transactivating properties." @default.
- W2018076163 created "2016-06-24" @default.
- W2018076163 creator A5000780491 @default.
- W2018076163 creator A5022482547 @default.
- W2018076163 creator A5028758045 @default.
- W2018076163 creator A5058785508 @default.
- W2018076163 creator A5060352280 @default.
- W2018076163 creator A5061513988 @default.
- W2018076163 creator A5069820574 @default.
- W2018076163 creator A5080468827 @default.
- W2018076163 creator A5087010545 @default.
- W2018076163 date "2004-03-01" @default.
- W2018076163 modified "2023-10-18" @default.
- W2018076163 title "Identification and characterization of a human smad3 splicing variant lacking part of the linker region" @default.
- W2018076163 cites W1553444759 @default.
- W2018076163 cites W1571622978 @default.
- W2018076163 cites W1589859980 @default.
- W2018076163 cites W1609684706 @default.
- W2018076163 cites W1636022999 @default.
- W2018076163 cites W1840163537 @default.
- W2018076163 cites W1964036489 @default.
- W2018076163 cites W1984760520 @default.
- W2018076163 cites W1988942273 @default.
- W2018076163 cites W2007044718 @default.
- W2018076163 cites W2011653571 @default.
- W2018076163 cites W2018454809 @default.
- W2018076163 cites W2039458025 @default.
- W2018076163 cites W2042720195 @default.
- W2018076163 cites W2067656705 @default.
- W2018076163 cites W2078868696 @default.
- W2018076163 cites W2094646101 @default.
- W2018076163 cites W2122146830 @default.
- W2018076163 cites W2143312146 @default.
- W2018076163 cites W2143763006 @default.
- W2018076163 cites W2145589640 @default.
- W2018076163 cites W2147769151 @default.
- W2018076163 cites W2151761027 @default.
- W2018076163 cites W2164615751 @default.
- W2018076163 cites W2166797651 @default.
- W2018076163 cites W2169237074 @default.
- W2018076163 cites W2321323503 @default.
- W2018076163 cites W4248750156 @default.
- W2018076163 cites W4294216491 @default.
- W2018076163 cites W4296588288 @default.
- W2018076163 doi "https://doi.org/10.1016/j.gene.2003.11.026" @default.
- W2018076163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14980711" @default.
- W2018076163 hasPublicationYear "2004" @default.
- W2018076163 type Work @default.
- W2018076163 sameAs 2018076163 @default.
- W2018076163 citedByCount "11" @default.
- W2018076163 countsByYear W20180761632016 @default.
- W2018076163 countsByYear W20180761632019 @default.
- W2018076163 countsByYear W20180761632021 @default.
- W2018076163 countsByYear W20180761632023 @default.
- W2018076163 crossrefType "journal-article" @default.
- W2018076163 hasAuthorship W2018076163A5000780491 @default.
- W2018076163 hasAuthorship W2018076163A5022482547 @default.
- W2018076163 hasAuthorship W2018076163A5028758045 @default.
- W2018076163 hasAuthorship W2018076163A5058785508 @default.
- W2018076163 hasAuthorship W2018076163A5060352280 @default.
- W2018076163 hasAuthorship W2018076163A5061513988 @default.
- W2018076163 hasAuthorship W2018076163A5069820574 @default.
- W2018076163 hasAuthorship W2018076163A5080468827 @default.
- W2018076163 hasAuthorship W2018076163A5087010545 @default.
- W2018076163 hasConcept C104317684 @default.
- W2018076163 hasConcept C105580179 @default.
- W2018076163 hasConcept C111335760 @default.
- W2018076163 hasConcept C153911025 @default.
- W2018076163 hasConcept C194583182 @default.
- W2018076163 hasConcept C36823959 @default.
- W2018076163 hasConcept C54009773 @default.
- W2018076163 hasConcept C54355233 @default.
- W2018076163 hasConcept C54458228 @default.
- W2018076163 hasConcept C67705224 @default.
- W2018076163 hasConcept C73758832 @default.
- W2018076163 hasConcept C81885089 @default.
- W2018076163 hasConcept C86803240 @default.
- W2018076163 hasConcept C95444343 @default.
- W2018076163 hasConceptScore W2018076163C104317684 @default.
- W2018076163 hasConceptScore W2018076163C105580179 @default.
- W2018076163 hasConceptScore W2018076163C111335760 @default.
- W2018076163 hasConceptScore W2018076163C153911025 @default.
- W2018076163 hasConceptScore W2018076163C194583182 @default.
- W2018076163 hasConceptScore W2018076163C36823959 @default.
- W2018076163 hasConceptScore W2018076163C54009773 @default.
- W2018076163 hasConceptScore W2018076163C54355233 @default.
- W2018076163 hasConceptScore W2018076163C54458228 @default.
- W2018076163 hasConceptScore W2018076163C67705224 @default.
- W2018076163 hasConceptScore W2018076163C73758832 @default.
- W2018076163 hasConceptScore W2018076163C81885089 @default.
- W2018076163 hasConceptScore W2018076163C86803240 @default.
- W2018076163 hasConceptScore W2018076163C95444343 @default.
- W2018076163 hasIssue "2" @default.
- W2018076163 hasLocation W20180761631 @default.
- W2018076163 hasLocation W20180761632 @default.
- W2018076163 hasOpenAccess W2018076163 @default.
- W2018076163 hasPrimaryLocation W20180761631 @default.
- W2018076163 hasRelatedWork W1532771184 @default.