FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018077354> ?p ?o ?g. }

• W2018077354 endingPage "1035" @default.
• W2018077354 startingPage "1029" @default.
• W2018077354 abstract "In this study, we have analyzed the possibility of inducing T cell responses against small cell lung cancer (SCLC), a still incurable tumor, by cytokine gene transfer approaches. By RT-PCR analysis most SCLC expressed the CTL-defined tumor antigens MAGE-3 (10/11), MAGE-1 (7/11) and less frequently BAGE (4/11) and GAGE1,2 (4/11). Although the surface expression of HLA class I molecules was low on most SCLC, thus preventing CTL recognition, treatment of the cells with IFN-gamma enhanced HLA-class I levels in all cases. Two MAGE3+ SCLC cell lines displaying the A2 HLA-class I allele, involved in MAGE-3 antigen presentation to CTL, were stably transfected with the IFN-gamma gene (alone or co-transfected with IL-2). IFN-gamma-transfected cells displayed a clearcut increase in expression of HLA-class I and beta 2-microglobulin at both protein and mRNA level, and of TAP-1 and TAP-2 mRNA. Perhaps more importantly, IFN-gamma transfected cells were recognized by the MAGE-3-specific A2-restricted antimelanoma CTL clone 297/22, while unmodified cells or cells transfected with the IL-2 gene alone were not. These data indicate that IFN-gamma gene transfection into HLA-deficient SCLC cells is able to restore their ability to present endogenous tumor antigens to CTL and that IFN-gamma gene transfer approaches may be attempted to induce specific CTL responses in SCLC." @default.
• W2018077354 created "2016-06-24" @default.
• W2018077354 creator A5012965242 @default.
• W2018077354 creator A5021597982 @default.
• W2018077354 creator A5032386417 @default.
• W2018077354 creator A5041252659 @default.
• W2018077354 creator A5053168505 @default.
• W2018077354 creator A5069510183 @default.
• W2018077354 creator A5072248019 @default.
• W2018077354 creator A5073844034 @default.
• W2018077354 creator A5084734114 @default.
• W2018077354 date "1997-10-01" @default.
• W2018077354 modified "2023-09-24" @default.
• W2018077354 title "IFN-γ gene transfer restores HLA-class I expression and MAGE-3 antigen presentation to CTL in HLA-deficient small cell lung cancer" @default.
• W2018077354 doi "https://doi.org/10.1038/sj.gt.3300489" @default.
• W2018077354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9415308" @default.
• W2018077354 hasPublicationYear "1997" @default.
• W2018077354 type Work @default.
• W2018077354 sameAs 2018077354 @default.
• W2018077354 citedByCount "44" @default.
• W2018077354 countsByYear W20180773542012 @default.
• W2018077354 countsByYear W20180773542013 @default.
• W2018077354 countsByYear W20180773542014 @default.
• W2018077354 countsByYear W20180773542015 @default.
• W2018077354 countsByYear W20180773542016 @default.
• W2018077354 countsByYear W20180773542017 @default.
• W2018077354 countsByYear W20180773542018 @default.
• W2018077354 countsByYear W20180773542019 @default.
• W2018077354 countsByYear W20180773542020 @default.
• W2018077354 countsByYear W20180773542021 @default.
• W2018077354 countsByYear W20180773542022 @default.
• W2018077354 crossrefType "journal-article" @default.
• W2018077354 hasAuthorship W2018077354A5012965242 @default.
• W2018077354 hasAuthorship W2018077354A5021597982 @default.
• W2018077354 hasAuthorship W2018077354A5032386417 @default.
• W2018077354 hasAuthorship W2018077354A5041252659 @default.
• W2018077354 hasAuthorship W2018077354A5053168505 @default.
• W2018077354 hasAuthorship W2018077354A5069510183 @default.
• W2018077354 hasAuthorship W2018077354A5072248019 @default.
• W2018077354 hasAuthorship W2018077354A5073844034 @default.
• W2018077354 hasAuthorship W2018077354A5084734114 @default.
• W2018077354 hasBestOaLocation W20180773541 @default.
• W2018077354 hasConcept C104317684 @default.
• W2018077354 hasConcept C108249834 @default.
• W2018077354 hasConcept C147483822 @default.
• W2018077354 hasConcept C147969180 @default.
• W2018077354 hasConcept C153911025 @default.
• W2018077354 hasConcept C167672396 @default.
• W2018077354 hasConcept C188280979 @default.
• W2018077354 hasConcept C203014093 @default.
• W2018077354 hasConcept C2776090121 @default.
• W2018077354 hasConcept C2777701055 @default.
• W2018077354 hasConcept C2778690821 @default.
• W2018077354 hasConcept C2780841837 @default.
• W2018077354 hasConcept C502942594 @default.
• W2018077354 hasConcept C54009773 @default.
• W2018077354 hasConcept C54355233 @default.
• W2018077354 hasConcept C81089528 @default.
• W2018077354 hasConcept C81885089 @default.
• W2018077354 hasConcept C83464605 @default.
• W2018077354 hasConcept C86803240 @default.
• W2018077354 hasConcept C8891405 @default.
• W2018077354 hasConceptScore W2018077354C104317684 @default.
• W2018077354 hasConceptScore W2018077354C108249834 @default.
• W2018077354 hasConceptScore W2018077354C147483822 @default.
• W2018077354 hasConceptScore W2018077354C147969180 @default.
• W2018077354 hasConceptScore W2018077354C153911025 @default.
• W2018077354 hasConceptScore W2018077354C167672396 @default.
• W2018077354 hasConceptScore W2018077354C188280979 @default.
• W2018077354 hasConceptScore W2018077354C203014093 @default.
• W2018077354 hasConceptScore W2018077354C2776090121 @default.
• W2018077354 hasConceptScore W2018077354C2777701055 @default.
• W2018077354 hasConceptScore W2018077354C2778690821 @default.
• W2018077354 hasConceptScore W2018077354C2780841837 @default.
• W2018077354 hasConceptScore W2018077354C502942594 @default.
• W2018077354 hasConceptScore W2018077354C54009773 @default.
• W2018077354 hasConceptScore W2018077354C54355233 @default.
• W2018077354 hasConceptScore W2018077354C81089528 @default.
• W2018077354 hasConceptScore W2018077354C81885089 @default.
• W2018077354 hasConceptScore W2018077354C83464605 @default.
• W2018077354 hasConceptScore W2018077354C86803240 @default.
• W2018077354 hasConceptScore W2018077354C8891405 @default.
• W2018077354 hasIssue "10" @default.
• W2018077354 hasLocation W20180773541 @default.
• W2018077354 hasLocation W20180773542 @default.
• W2018077354 hasOpenAccess W2018077354 @default.
• W2018077354 hasPrimaryLocation W20180773541 @default.
• W2018077354 hasRelatedWork W1967779669 @default.
• W2018077354 hasRelatedWork W1969083863 @default.
• W2018077354 hasRelatedWork W1969921871 @default.
• W2018077354 hasRelatedWork W1991717697 @default.
• W2018077354 hasRelatedWork W2000941383 @default.
• W2018077354 hasRelatedWork W2018685486 @default.
• W2018077354 hasRelatedWork W2065869927 @default.
• W2018077354 hasRelatedWork W2069363977 @default.
• W2018077354 hasRelatedWork W2749039499 @default.
• W2018077354 hasRelatedWork W2992080162 @default.
• W2018077354 hasVolume "4" @default.

• next