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• W2018078990 abstract "The retinal thickness analyser (RTA, Talia aatechnologies Ltd. Mevaseret Zion, Israel) is a novel non-invasive instrument developed for multiple optical cross-sectional retinal visualization that provides quantitative measurements of retinal thickness (Zeimer et al. 1996). The RTA operates on the principle of laser biomicroscopy (Zeimer et al. 1989) covering a zone of about 20° × 20° around the fovea. A pilot study demonstrated the ability of RTA to detect localized thinning of the retina in glaucomatous patients (Asrani et al. 1997), indicating a local loss of nerve fibres. In the present study we investigated the reproducibility of retinal thickness measurements in glaucomatous patients and control subjects. Twelve patients (6 male and 6 female) affected by bilateral primary open angle glaucoma controlled with hypotensive medication and 10 healthy subjects (6 male and 4 female) were enrolled in this clinical study. Corneal refractive power and refractive error were examined in all subjects and one eye each was randomly selected. Before RTA retinal thickness measurements were made, the pupil was dilated to at least 5 mm diameter. A green helium neon laser was scanned by a slit beam in a 2 × 2 mm area of the posterior pole. Nine areas were scanned, covering the central 20° of the fundus. All the examinations were performed by a trained operator. The images were analysed by an automated software and thickness map and a large number of global indices were calculated: the posterior pole average thickness (PPA), posterior pole pattern deviation (PPPD) and posterior pole corrected pattern deviation (PPCPD) were used in the present study to assess the reproducibility. Two different reproducibilities were assessed: the intravisit reproducibility, evaluating three scans in a single session, and the intervisit reproducibility, evaluating two scans obtained from two different sessions. Reproducibility was calculated using the coefficient of variation (CV) of PPA, PPPD and PPCPD. No statistically significant difference in mean age between the glaucomatous patients (52.6 ± 6.3 years) and the controls (50.3 ± 5.4) was found. Table 1 shows the values of the posterior pole indices in the normal and the glaucomatous subjects. The intravisit reproducibility was 3.4% for PPA, 5.3% for PPPD and 4.9% for PPCPD in the glaucomatous patients and 3.1%, 4.6% and 4.3%, respectively, in the normal subjects. Table 2 exhibits the intervisit reproducibility of the RTA measurements: the CV of PPA ranged from 5.6% in the glaucomatous patients to 4.8% in the healthy subjects. The results of this study indicate that RTA is a highly reproducible method for measuring retinal thickness. The intervisit variability of RTA measurements of 5.6% in glaucomatous patients, corresponding to ± 9 mm, is in accord with Weimberger (Weimberger et al.), who found a CV of 5.9% in normal eyes. In conclusion, RTA is a non-invasive, objective and reproducible method to visualize the quantitative profile of the retinal thickness in glaucomatous eyes." @default.
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• W2018078990 date "2002-10-01" @default.
• W2018078990 modified "2023-09-23" @default.
• W2018078990 title "Reproducibility of retinal thickness measurements with retinal thickness analyser in healthy and glaucomatous subjects" @default.
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• W2018078990 doi "https://doi.org/10.1034/j.1600-0420.80.s236.25.x" @default.
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