FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018079314> ?p ?o ?g. }

• W2018079314 endingPage "357" @default.
• W2018079314 startingPage "343" @default.
• W2018079314 abstract "Lipofuscin and ceroid are usually held responsible for impaired cellular performance, via oxidative damage and the irreversible accumulation of fluorescent products of lipid peroxidation. The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are inherited neurodegenerative diseases characterized by intracellular accumulation of fluorescent lipofuscin-like bodies. However these bodies are lysosomes packed with a particular protein, subunit c of mitochondrial ATP synthase; not the result of oxidative damage. No individual storage body component was fluorescent nor were solutions of total storage bodies. UV–vis spectra confirmed the lack of a fluorophor. Crystals of non-fluorescent albumin and reconstituted storage bodies were fluorescent in glycerol suspensions. This fluorescence is probably caused by interference of light reflected from the protein array, as is often observed in protein crystals. Other lipofuscins may be secondary lysosomes with a high protein content and the source of fluorescence the same. The neurodegeneration associated with lipofuscin accumulation may be caused by that accumulation, or may be a separate manifestation of aging. Neuronal cell cultures offer a way to study these processes. Subunit c accumulation has been observed in cerebral bipolar neurons cultured from 90 day NCL affected sheep foetuses. Neurons from different parts of the brain behave differently. Normal 108 day cerebellar granule neurons migrated into clumps when cultured with tri-iodothyronine, but affected cerebellar neurons did not, nor did normal or affected cerebral neurons." @default.
• W2018079314 created "2016-06-24" @default.
• W2018079314 creator A5010560667 @default.
• W2018079314 creator A5018700114 @default.
• W2018079314 creator A5026493097 @default.
• W2018079314 creator A5038359452 @default.
• W2018079314 date "2002-05-01" @default.
• W2018079314 modified "2023-10-18" @default.
• W2018079314 title "The origin of fluorescence in the neuronal ceroid lipofuscinoses (Batten disease) and neuron cultures from affected sheep for studies of neurodegeneration" @default.
• W2018079314 cites W116205829 @default.
• W2018079314 cites W1545013128 @default.
• W2018079314 cites W1933952120 @default.
• W2018079314 cites W1967142924 @default.
• W2018079314 cites W1971102767 @default.
• W2018079314 cites W1972499051 @default.
• W2018079314 cites W1974310748 @default.
• W2018079314 cites W1985550040 @default.
• W2018079314 cites W1986119684 @default.
• W2018079314 cites W1986612956 @default.
• W2018079314 cites W1987616971 @default.
• W2018079314 cites W1996488187 @default.
• W2018079314 cites W2007071486 @default.
• W2018079314 cites W2012642064 @default.
• W2018079314 cites W2020978481 @default.
• W2018079314 cites W2022899166 @default.
• W2018079314 cites W2030598185 @default.
• W2018079314 cites W2032826250 @default.
• W2018079314 cites W2033584772 @default.
• W2018079314 cites W2038027009 @default.
• W2018079314 cites W2040107841 @default.
• W2018079314 cites W2049132759 @default.
• W2018079314 cites W2058677460 @default.
• W2018079314 cites W2063611222 @default.
• W2018079314 cites W2081844190 @default.
• W2018079314 cites W2082293178 @default.
• W2018079314 cites W2113756453 @default.
• W2018079314 cites W2115596765 @default.
• W2018079314 cites W2147113738 @default.
• W2018079314 cites W2149204394 @default.
• W2018079314 cites W2165298990 @default.
• W2018079314 cites W2313238805 @default.
• W2018079314 cites W2324416011 @default.
• W2018079314 cites W2337362397 @default.
• W2018079314 doi "https://doi.org/10.1016/s0167-4943(02)00011-0" @default.
• W2018079314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14764335" @default.
• W2018079314 hasPublicationYear "2002" @default.
• W2018079314 type Work @default.
• W2018079314 sameAs 2018079314 @default.
• W2018079314 citedByCount "27" @default.
• W2018079314 countsByYear W20180793142012 @default.
• W2018079314 countsByYear W20180793142013 @default.
• W2018079314 countsByYear W20180793142014 @default.
• W2018079314 countsByYear W20180793142015 @default.
• W2018079314 countsByYear W20180793142016 @default.
• W2018079314 countsByYear W20180793142017 @default.
• W2018079314 countsByYear W20180793142018 @default.
• W2018079314 countsByYear W20180793142019 @default.
• W2018079314 countsByYear W20180793142020 @default.
• W2018079314 countsByYear W20180793142021 @default.
• W2018079314 crossrefType "journal-article" @default.
• W2018079314 hasAuthorship W2018079314A5010560667 @default.
• W2018079314 hasAuthorship W2018079314A5018700114 @default.
• W2018079314 hasAuthorship W2018079314A5026493097 @default.
• W2018079314 hasAuthorship W2018079314A5038359452 @default.
• W2018079314 hasConcept C104292427 @default.
• W2018079314 hasConcept C104317684 @default.
• W2018079314 hasConcept C121332964 @default.
• W2018079314 hasConcept C126322002 @default.
• W2018079314 hasConcept C169760540 @default.
• W2018079314 hasConcept C185592680 @default.
• W2018079314 hasConcept C186198217 @default.
• W2018079314 hasConcept C2776925932 @default.
• W2018079314 hasConcept C2778230176 @default.
• W2018079314 hasConcept C2778650512 @default.
• W2018079314 hasConcept C2779134260 @default.
• W2018079314 hasConcept C2779652256 @default.
• W2018079314 hasConcept C55493867 @default.
• W2018079314 hasConcept C57600042 @default.
• W2018079314 hasConcept C62520636 @default.
• W2018079314 hasConcept C71924100 @default.
• W2018079314 hasConcept C86803240 @default.
• W2018079314 hasConcept C91881484 @default.
• W2018079314 hasConcept C95444343 @default.
• W2018079314 hasConceptScore W2018079314C104292427 @default.
• W2018079314 hasConceptScore W2018079314C104317684 @default.
• W2018079314 hasConceptScore W2018079314C121332964 @default.
• W2018079314 hasConceptScore W2018079314C126322002 @default.
• W2018079314 hasConceptScore W2018079314C169760540 @default.
• W2018079314 hasConceptScore W2018079314C185592680 @default.
• W2018079314 hasConceptScore W2018079314C186198217 @default.
• W2018079314 hasConceptScore W2018079314C2776925932 @default.
• W2018079314 hasConceptScore W2018079314C2778230176 @default.
• W2018079314 hasConceptScore W2018079314C2778650512 @default.
• W2018079314 hasConceptScore W2018079314C2779134260 @default.
• W2018079314 hasConceptScore W2018079314C2779652256 @default.
• W2018079314 hasConceptScore W2018079314C55493867 @default.
• W2018079314 hasConceptScore W2018079314C57600042 @default.
• W2018079314 hasConceptScore W2018079314C62520636 @default.

• next