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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018080111> ?p ?o ?g. }

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• W2018080111 abstract "Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [β-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses." @default.
• W2018080111 created "2016-06-24" @default.
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• W2018080111 date "1978-03-24" @default.
• W2018080111 modified "2023-09-23" @default.
• W2018080111 title "Dual Actions of Substance P on Nociception: Possible Role of Endogenous Opioids" @default.
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• W2018080111 doi "https://doi.org/10.1126/science.204012" @default.
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