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- W2018082906 abstract "We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010." @default.
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- W2018082906 date "2010-11-10" @default.
- W2018082906 modified "2023-09-28" @default.
- W2018082906 title "Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants" @default.
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- W2018082906 doi "https://doi.org/10.1002/jbm.a.32977" @default.
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